Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 12/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959266 | 0.85 | HTT (0.60) | HMGCRPTPN1ALOX5ALDH1A1CYP3A4 | |
| SCHEMBL9417928 | 0.79 | NR1H4 (0.44) | HMGCRALDH1A1CNR2KDM4E | |
| SCHEMBL3486415 | 0.78 | ALDH1A1 (0.57) | HMGCRPTPN1ALOX5ALDH1A1CYP3A4 | |
| SCHEMBL9417934 | 0.77 | PTPN1 (0.52) | PTPN1CYP3A4HTT | |
| SCHEMBL9417859 | 0.76 | ALOX5 (0.46) | PTPN1ALOX5ALDH1A1CYP3A4AR | |
| SCHEMBL5339173 | 0.75 | ALOX5 (0.41) | PTPN1ALOX5ALDH1A1CYP3A4AR | |
| SCHEMBL28052190 | 0.75 | HMGCR (0.83) | HMGCRALDH1A1CYP3A4PTGS1KDM4E | |
| SCHEMBL8155803 | 0.74 | ALOX5 (0.49) | HMGCRPTPN1ALOX5ALDH1A1CYP3A4 | |
| SCHEMBL28167755 | 0.74 | HMGCR (0.75) | HMGCRALDH1A1CYP3A4KDM4EHTT | |
| SCHEMBL9417886 | 0.73 | L3MBTL1 (0.41) | HMGCRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538123-B2 | Indole derivative having piperidine ring | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-20070219179-A1 | Indole Derivative Having Piperidine Ring | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-09-20 | — | — | US | disclosed |
| EP-1757599-A1 | INDOLE DERIVATIVES HAVING PIPERIDINE RINGS | Eisai R&D Management Co., Ltd. (JP) | 2007-02-28 | — | — | EP | disclosed |
| US-20050256103-A1 | Indole derivative having piperidine ring | EISAI CO., LTD. | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219179-A1 | Indole Derivative Having Piperidine Ring | HTR5A, HTR2C, HTR1A | HMGCR 4711/4885PTPN1 1583/4885ALOX5 812/4885 |
| US-20050256103-A1 | Indole derivative having piperidine ring | HTR5A, HTR2C, HTR1A | HMGCR 4641/4885PTPN1 1339/4885ALOX5 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.