Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.49 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966252 | 0.90 | PTGDR2 (0.55) | PTGDR2PTGDRRAPGEF4CYP2C9 | |
| SCHEMBL3973994 | 0.87 | PTGDR2 (0.40) | PTGDR2RAPGEF4MEN1KMT2ACYP2C19 | |
| SCHEMBL3967733 | 0.87 | PTGDR2 (0.40) | PTGDR2RAPGEF4NOD2NOD1MEN1 | |
| SCHEMBL3968885 | 0.83 | PPME1 (0.37) | PTGDR2RAPGEF4HTR6ALDH1A1 | |
| SCHEMBL3967149 | 0.80 | RAPGEF4 (0.42) | PTGDR2PTGDRRAPGEF4NOD2NOD1 | |
| SCHEMBL3967117 | 0.80 | POLB (0.36) | PTGDR2RAPGEF4HTR6CYP2C9 | |
| SCHEMBL3967602 | 0.79 | RAPGEF4 (0.34) | PTGDR2RAPGEF4HTR6 | |
| SCHEMBL3967784 | 0.79 | RAPGEF4 (0.35) | PTGDR2RAPGEF4MEN1KMT2AHTR6 | |
| SCHEMBL3968063 | 0.78 | HTR6 (0.34) | PTGDR2RAPGEF4HTR6ALDH1A1 | |
| SCHEMBL3974788 | 0.78 | PTGDR2 (0.46) | PTGDR2PTGDRRAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |