Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | PPME1 | Q9Y570 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29221130 | 0.81 | RAPGEF4 (0.59) | ATMCTSGCMA1PPME1TRIM24 | |
| SCHEMBL14397867 | 0.77 | FABP4 (0.52) | ATMPPME1 | |
| SCHEMBL1616366 | 0.76 | PPME1 (0.60) | METHTR6ATMPPME1TRIM24 | |
| SCHEMBL26181018 | 0.76 | GAA (0.51) | METMEN1ALDH1A1KMT2A | |
| SCHEMBL3964674 | 0.75 | PPME1 (0.58) | CYP3A4PPME1RAPGEF4ALDH1A1KMT2A | |
| SCHEMBL3966831 | 0.72 | MET (0.49) | METHTR6CYP3A4PPME1MEN1 | |
| SCHEMBL6419604 | 0.71 | PPME1 (0.67) | HTR6PPME1HTR2AHTR2CTRIM24 | |
| SCHEMBL14734960 | 0.70 | KDM4E (0.60) | METHTR6HTR2AHTR2CDRD3 | |
| SCHEMBL30558132 | 0.70 | KDM4E (0.60) | METHTR6HTR2AHTR2CDRD3 | |
| SCHEMBL27688842 | 0.70 | MET (0.47) | METP2RX7HTR6CYP3A4CTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |