Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 10/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | PPME1 | Q9Y570 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964674 | 0.83 | PPME1 (0.58) | ALDH1A1KMT2AMMP2CYP3A4PPME1 | |
| SCHEMBL1616366 | 0.80 | PPME1 (0.60) | METMEN1ALDH1A1KMT2AHTR6 | |
| SCHEMBL2457308 | 0.73 | RAPGEF4 (0.58) | ALDH1A1MMP2PPME1PKM | |
| SCHEMBL3968075 | 0.73 | PPME1 (0.55) | MEN1KMT2AMMP2HTR6PPME1 | |
| SCHEMBL3964676 | 0.73 | PPME1 (0.45) | HTR6CYP3A4PPME1 | |
| SCHEMBL3968076 | 0.72 | MET (0.47) | METMEN1ALDH1A1KMT2AHTR6 | |
| SCHEMBL5247297 | 0.71 | RAPGEF4 (0.60) | MEN1ALDH1A1KMT2APPME1MAPT | |
| SCHEMBL3967048 | 0.70 | PPME1 (0.43) | ALDH1A1HTR6PPME1 | |
| SCHEMBL10726996 | 0.68 | ALDH1A1 (0.86) | MEN1ALDH1A1KMT2AMMP2PKM | |
| SCHEMBL2460281 | 0.68 | TRIM24 (0.52) | ALDH1A1KMT2AHTR6PPME1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |