Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPME1 | Q9Y570 | 4/20 | 0.67 |
| ▸ | HTR6 | P50406 | 6/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PKLR | P30613 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968075 | 0.78 | PPME1 (0.55) | PPME1HTR6PKMTRIM24TRIM33 | |
| SCHEMBL3968076 | 0.71 | MET (0.47) | PPME1HTR6ALDH1A1TRIM24TRIM33 | |
| SCHEMBL29221130 | 0.71 | RAPGEF4 (0.59) | PPME1ALDH1A1TRIM24TRIM33RAPGEF4 | |
| SCHEMBL6420296 | 0.70 | MEN1 (0.53) | PPME1PKMALDH1A1MAPT | |
| SCHEMBL1616366 | 0.69 | PPME1 (0.60) | PPME1HTR6ALDH1A1TRIM24TRIM33 | |
| SCHEMBL5247297 | 0.67 | RAPGEF4 (0.60) | PPME1ALDH1A1MAPTTRIM24TRIM33 | |
| SCHEMBL2460281 | 0.67 | TRIM24 (0.52) | PPME1HTR6ALDH1A1TRIM24TRIM33 | |
| SCHEMBL2464163 | 0.66 | TRIM24 (0.42) | PPME1ALDH1A1TRIM24TRIM33 | |
| SCHEMBL3964674 | 0.66 | PPME1 (0.58) | PPME1PKMALDH1A1RAPGEF4 | |
| SCHEMBL2457308 | 0.66 | RAPGEF4 (0.58) | PPME1PKMALDH1A1TRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861419-B2 | Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20020010169-A1 | Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2002-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010169-A1 | Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP1, CASP14, CASP4 | PPME1 693/4885HTR6 2603/4885PKM 2265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.