Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3976405 | 0.93 | ALDH1A1 (0.49) | ALDH1A1NPSR1L3MBTL1TSHRHTR7 | |
| SCHEMBL3976402 | 0.84 | DRD2 (0.56) | ALDH1A1NPSR1TSHRSMN1; SMN2DRD4 | |
| SCHEMBL3974263 | 0.83 | HTR2A (0.49) | TSHRHTR7SMN1; SMN2DRD2LMNA | |
| SCHEMBL3980647 | 0.82 | CACNA1G (0.55) | ALDH1A1HTR7DRD4DRD2POLB | |
| SCHEMBL3973174 | 0.78 | KCNH2 (0.49) | HTR7DRD4DRD2CACNA1G | |
| SCHEMBL3974512 | 0.77 | MAPT (0.42) | ALDH1A1HTR7DRD2POLBKDM4E | |
| SCHEMBL3973177 | 0.77 | KCNH2 (0.48) | DRD2HSD17B10 | |
| SCHEMBL3974266 | 0.76 | HTR2A (0.49) | TSHRHTR7DRD2LMNA | |
| SCHEMBL3187667 | 0.76 | CACNA1G (0.63) | ALDH1A1NPSR1L3MBTL1TSHRHTR7 | |
| SCHEMBL3980650 | 0.75 | DRD2 (0.51) | ALDH1A1DRD4DRD2KDM4ECACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | claimed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | claimed |