Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969996 | 0.80 | MLYCD (0.43) | ALDH1A1NPSR1LMNANOS3NOS1 | |
| SCHEMBL3968468 | 0.79 | MAPK1 (0.40) | MAPTKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL3973730 | 0.77 | ADRA2A (0.46) | MAPTKDM4EALDH1A1POLBGAA | |
| SCHEMBL5537171 | 0.74 | SLC6A4 (0.41) | MAPTSERPINE1LMNAL3MBTL1 | |
| SCHEMBL3972855 | 0.74 | SMN1; SMN2 (0.47) | KDM4EALDH1A1GRIN2BMLYCDSMN1; SMN2 | |
| SCHEMBL4096326 | 0.74 | POLB (0.36) | KDM4ENPC1ALDH1A1POLBRAB9A | |
| SCHEMBL3973752 | 0.74 | ALDH1A1 (0.46) | MAPTALDH1A1GAARAB9ATDP1 | |
| SCHEMBL2649697 | 0.73 | SERPINE1 (0.54) | SERPINE1 | |
| SCHEMBL11816669 | 0.73 | ALDH1A1 (0.52) | MAPTKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL3971781 | 0.71 | ALDH1A1 (0.46) | MAPTKDM4EALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016061-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | Glaxo Group Limited (GB) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007122241-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-11-01 | — | — | WO | disclosed |