Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28894377 | 0.84 | KMT2A (0.48) | KMT2AATMCES2CES1KDM4E | |
| SCHEMBL2975869 | 0.80 | THRB (0.55) | KMT2AATMCES2CES1KDM4E | |
| SCHEMBL8858845 | 0.79 | KMT2A (0.46) | KMT2AKDM4EMEN1GAACA1 | |
| SCHEMBL57245 | 0.78 | KMT2A (0.50) | KMT2AATMCES2CES1KDM4E | |
| SCHEMBL27495352 | 0.77 | CYP4F2 (0.43) | KMT2ACES2CES1CA1 | |
| SCHEMBL11291636 | 0.77 | ELANE (0.46) | KMT2AKDM4EMEN1GAACA1 | |
| SCHEMBL2129488 | 0.77 | LMNA (0.61) | KMT2AATMMEN1GAAALDH1A1 | |
| SCHEMBL27819405 | 0.77 | TPMT (0.39) | KMT2ACA1CA2LMNA | |
| SCHEMBL6741501 | 0.77 | CYP11B1 (0.47) | KMT2ACES2CES1MEN1SMN1; SMN2 | |
| SCHEMBL28744273 | 0.77 | LDHA (0.45) | KMT2ACES2CES1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057164-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008021781-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | WO | disclosed |