Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446786 | 0.94 | CYP3A4 (0.68) | HPGDCYP3A4ALDH1A1ADORA3ADRA2A | |
| SCHEMBL4760053 | 0.86 | CYP3A4 (0.71) | HPGDCYP3A4ALDH1A1ADORA3C5AR1 | |
| SCHEMBL1031237 | 0.85 | HPGD (0.73) | HPGDCYP3A4ALDH1A1C5AR1L3MBTL1 | |
| SCHEMBL2336285 | 0.83 | ALDH1A1 (0.45) | HPGDCYP3A4ALDH1A1ADRA2AL3MBTL1 | |
| SCHEMBL10561004 | 0.80 | HPGD (0.49) | HPGDCYP3A4ALDH1A1ADORA3ADRA2A | |
| SCHEMBL3240884 | 0.79 | HPGD (0.54) | HPGDCYP3A4ADORA3 | |
| SCHEMBL29738657 | 0.79 | ADRA2A (0.45) | HPGDCYP3A4ALDH1A1ADRA2A | |
| SCHEMBL29142975 | 0.78 | CYP3A4 (1.00) | HPGDCYP3A4ALDH1A1ADORA3C5AR1 | |
| SCHEMBL3977468 | 0.78 | SMN1; SMN2 (0.48) | HPGDCYP3A4ALDH1A1ADORA3L3MBTL1 | |
| SCHEMBL7178960 | 0.77 | ADORA2B (0.47) | HPGDCYP3A4ALDH1A1ADRA2ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515972-B1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | HOFFMANN LA ROCHE (CH) | 2009-05-13 | — | — | EP | disclosed |
| EP-1515972-B1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | HOFFMANN LA ROCHE (CH) | 2009-05-13 | — | — | EP | disclosed |
| US-7135475-B2 | Antidiabetic agents | HOFFMANN-LA ROCHE INC. (US) | 2006-11-14 | — | — | US | disclosed |
| EP-1515972-A1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-23 | — | — | EP | disclosed |
| EP-1510545-A2 | 1,3 substituted 6-aminouraciles to stabilize halogenated polymers | Wehner, Wolfgang, Dr. (DE) | 2005-03-02 | — | — | EP | disclosed |
| US-20040014766-A1 | Amide substituted xanthine derivatives | HOFFMANN-LA ROCHE INC. | 2004-01-22 | — | — | US | disclosed |
| WO-2003106459-A1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-24 | — | — | WO | disclosed |
| US-6274654-B1 | 1,3-Disubstituted 6-aminouracils for stabilizing halogenated polymers | WITCO VINYL ADDITIVES GMBH (DE) | 2001-08-14 | — | — | US | disclosed |
| EP-0967245-A1 | 1,3 substituted 6-aminouraciles to stabilize halogenated polymers | Witco Vinyl Additives GmbH (DE) | 1999-12-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014766-A1 | Amide substituted xanthine derivatives | GYS2, GLS2, PYGL | HPGD 469/4885CYP3A4 86/4885ALDH1A1 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.