Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9505755 | 0.88 | HTT (0.44) | ENPP2PTGS2 | |
| SCHEMBL7087936 | 0.85 | PTGS2 (0.44) | PTGS2PTGDR2CYP3A4 | |
| SCHEMBL20300446 | 0.82 | CA2 (0.42) | ENPP2CA1CA2PTGS2 | |
| SCHEMBL6581495 | 0.82 | ENPP2 (0.46) | ENPP2CA1CA2PTGS2KCNJ1 | |
| SCHEMBL13231429 | 0.80 | ENPP2 (0.54) | ENPP2CA1CA2PTGS2 | |
| SCHEMBL19258515 | 0.80 | CA2 (0.43) | CA1CA2 | |
| SCHEMBL3539406 | 0.80 | CYP3A4 (0.52) | CA1CA2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL710799 | 0.79 | PSIP1 (0.63) | CA1CA2CYP3A4CYP2C9 | |
| SCHEMBL2376239 | 0.79 | ENPP2 (0.72) | ENPP2PTGS2 | |
| SCHEMBL20323503 | 0.79 | DRD1 (0.42) | CA1CA2PTGS2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 436 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-207348145-U | A kind of Emergency water supply device for the chloro- 4- methylsulfonyltoluenes reaction kettles of 2- | 倍合德华强(连云港)医药化工科技有限公司 | 2018-05-11 | — | — | CN | claimed |
| CN-104086466-B | The preparation method of the thiamphenicol benzoic acid of 2 chlorine 4 | 倍合德华强(连云港)医药化工科技有限公司 | 2017-11-21 | — | — | CN | claimed |
| CN-105017101-B | Synthesizing method of 2-chloro-4-(methylsulfonyl)benzoic acid | 浙江大学 | 2017-03-22 | — | — | CN | claimed |
| CN-105017101-A | Synthesizing method of 2-chloro-4-(methylsulfonyl)benzoic acid | UNIV ZHEJIANG | 2015-11-04 | — | — | CN | claimed |
| CN-104086466-A | Preparation method of 2-chloro-4-methylsulfonylbenzoic acid | BEI HE DE HUA QIANG LIANYUNGANG PHARMACEUTICAL & CHEMICAL TECHNOLOGY CO LTD | 2014-10-08 | — | — | CN | claimed |
| CN-102627591-B | Preparation method of 2-chloro-4-methylsulfonylbenzoic acid | SUZHOU LUOSEN AUX IES CO LTD | 2013-11-06 | — | — | CN | claimed |
| US-7355048-B2 | Process for preparing 1-(6-methylpyridin-3-yl)-2-[4- (methylsulphonyl)phenyl]ethanone | LONZA LTD. (CH) | 2008-04-08 | — | — | US | claimed |
| CN-1281589-C | Preparation of 1-(6-methylpyridin-3-yl)-2-(4-methylsulfonyl-phenyl)ethanon | LONZA AG (CH) | 2006-10-25 | — | — | CN | claimed |
| US-20050159458-A1 | Process for preparing 1-( 6-methylpyridin-3-yl)-2-[4- (methylsulfonyl)phenyl]ethanone | KUO DAVID (US) | 2005-07-21 | — | — | US | claimed |
| CN-1583723-A | Preparation of 1-(6-methylpyridin-3-yl)-2-(4-methylsulfonyl-phenyl)ethanon | LONZA AG (CH) | 2005-02-23 | — | — | CN | claimed |
| EP-1394149-B1 | Process for the preparation of 1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)-phenyl]ethanon | LONZA AG (CH) | 2005-01-19 | — | — | EP | claimed |
| US-20250170117-A1 | MODULATORS OF ACKR3 AND USES THEREOF | INTERAX BIOTECH AG (CH) | 2025-05-29 | — | — | US | disclosed |
| US-20250099448-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2025-03-27 | — | — | US | disclosed |
| CN-119431200-A | Synthesis method of etoricoxib intermediate | 南京杰运医药科技有限公司 | 2025-02-14 | — | — | CN | disclosed |
| EP-4486739-A1 | MODULATORS OF ACKR3 AND USES THEREOF | InterAx Biotech AG (CH) | 2025-01-08 | — | — | EP | disclosed |
| EP-0234045-A2 | A pyrazole oxime derivative and its production and use | NIHON NOHYAKU CO., LTD. (JP) | 1987-09-02 | — | — | EP | disclosed |
| US-4536599-A | HYDROLYZING THE NITRILE DERIVATIVE TO THE AMIDE USING AN ORGANIC QUATERNARY AMINE SALT CATALYST; EFFICIENCY | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-08-20 | — | — | US | disclosed |
| EP-0093484-A2 | Antibacterial monic acid derivatives | BEECHAM GROUP PLC (GB) | 1983-11-09 | — | — | EP | disclosed |
| EP-0008532-B1 | SYNTHESIS OF AMINES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-07-20 | — | — | EP | disclosed |
| EP-0008532-A1 | Synthesis of amines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250170117-A1 | MODULATORS OF ACKR3 AND USES THEREOF | ACKR3, PROKR2, PROKR1 | ENPP2 165/4885CA1 3356/4885CA2 2281/4885 |
| US-20250099448-A1 | HETEROCYCLIC COMPOUNDS | OPRM1, CYP1A1, CYP3A4 | ENPP2 3934/4885CA1 3030/4885CA2 4628/4885 |
| US-20050159458-A1 | Process for preparing 1-( 6-methylpyridin-3-yl)-2-[4- (methylsulfonyl)phenyl]ethanone | SKP1, AZI2, EEF2K | ENPP2 2967/4885CA1 4716/4885CA2 4578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.