Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | ME2 | P23368 | 7/20 | 0.49 |
| ▸ | ME1 | P48163 | 7/20 | 0.49 |
| ▸ | ME3 | Q16798 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041242 | 0.88 | MAPT (0.68) | MAPTALDH1A1KDM4EPKMTDP1 | |
| SCHEMBL7106841 | 0.81 | KDM4E (0.61) | MAPTALDH1A1KDM4EPKMTDP1 | |
| SCHEMBL8931737 | 0.79 | DRD4 (0.67) | MAPTALDH1A1KDM4EPKMGAA | |
| SCHEMBL27936730 | 0.78 | TDP1 (0.66) | MAPTALDH1A1KDM4ETDP1GAA | |
| SCHEMBL3043144 | 0.78 | ALDH1A1 (0.57) | MAPTALDH1A1KDM4EPKMTDP1 | |
| SCHEMBL657027 | 0.78 | ALDH1A1 (0.57) | MAPTALDH1A1KDM4EPKMTDP1 | |
| SCHEMBL5539457 | 0.77 | ME2 (0.63) | MAPTALDH1A1KDM4EPKMGAA | |
| SCHEMBL3055201 | 0.77 | MAPT (0.63) | MAPTALDH1A1KDM4EPKMTDP1 | |
| SCHEMBL18938503 | 0.77 | MAPT (0.57) | MAPTALDH1A1KDM4EPKMTDP1 | |
| SCHEMBL13389789 | 0.77 | MAPT (0.57) | MAPTALDH1A1KDM4EPKMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541478-B2 | Coumarin derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-02 | — | — | US | disclosed |
| US-20070197636-A1 | Coumarin Derivative And Use Thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | US | disclosed |
| US-20070179154-A1 | Coumarin derivatives, process for their production and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-02 | — | — | US | disclosed |
| CN-1950352-A | Coumarin derivative and use thereof | TAKEDA PHARMACEUTICAL (JP) | 2007-04-18 | — | — | CN | disclosed |
| EP-1720850-A1 | COUMARIN DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2006-11-15 | — | — | EP | disclosed |
| US-20060035865-A1 | Lipid-rich plaque regressing agents | TERASHITA ZEN-ICHI | 2006-02-16 | — | — | US | disclosed |
| US-6974806-B2 | Lipid-rich plaque inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-12-13 | — | — | US | disclosed |
| WO-2005082879-A1 | COUMARIN DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-09-09 | — | — | WO | disclosed |
| CN-1615305-A | Coumarin derivatives, process for their production and use thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2005-05-11 | — | — | CN | disclosed |
| US-20050020634-A1 | Coumarin derivatives, process for their production and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-01-27 | — | — | US | disclosed |
| EP-1471064-A1 | COUMARIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2004-10-27 | — | — | EP | disclosed |
| US-20030232809-A1 | Lipid-rich plaque inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-12-18 | — | — | US | disclosed |
| CN-1441794-A | Lipid-rich plaque degrading agent | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-10 | — | — | CN | disclosed |
| EP-1302470-A1 | LIPID-RICH PLAQUE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2003-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020634-A1 | Coumarin derivatives, process for their production and use thereof | CBR1, ACAT2, CBR3 | MAPT 1343/4885ALDH1A1 1151/4885KDM4E 1328/4885 |
| US-20060035865-A1 | Lipid-rich plaque regressing agents | NR1H2, NR1H3, LDLR | MAPT 3908/4885ALDH1A1 3900/4885KDM4E 2317/4885 |
| US-20070197636-A1 | Coumarin Derivative And Use Thereof | CBR3, HCCS, CBR1 | MAPT 4209/4885ALDH1A1 300/4885KDM4E 2544/4885 |
| US-20030232809-A1 | Lipid-rich plaque inhibitors | LDLR, NR1H2, NR1H3 | MAPT 4199/4885ALDH1A1 2807/4885KDM4E 1720/4885 |
| US-20070179154-A1 | Coumarin derivatives, process for their production and use thereof | CBR1, CBR3, ACAT2 | MAPT 1282/4885ALDH1A1 1383/4885KDM4E 1132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.