Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800078 | 0.84 | L3MBTL1 (0.38) | L3MBTL1GAAUSP7ALDH1A1TSHR | |
| SCHEMBL24106950 | 0.82 | OPRD1 (0.46) | GAACYP2D6ALDH1A1TSHRRIPK1 | |
| Simufilam SCHEMBL12627054 | 0.80 | MC4R (0.46) | GAAALDH1A1LMNAMAPK1MEN1 | |
| SCHEMBL1800769 | 0.80 | CXCR3 (0.41) | L3MBTL1GAAUSP7CYP2D6ALDH1A1 | |
| SCHEMBL2934997 | 0.80 | CXCR3 (0.41) | L3MBTL1GAAUSP7CYP2D6ALDH1A1 | |
| Simufilam SCHEMBL22361808 | 0.79 | MC4R (0.45) | GAAALDH1A1LMNAMAPK1MEN1 | |
| Simufilam SCHEMBL22361802 | 0.79 | MC4R (0.45) | GAAALDH1A1LMNAMAPK1MEN1 | |
| Hydrochloric Acid SCHEMBL1800156 | 0.79 | CCR5 (0.41) | L3MBTL1GAAUSP7CYP2D6ALDH1A1 | |
| SCHEMBL24106959 | 0.79 | RIPK1 (0.39) | CYP2D6ALDH1A1TSHRRIPK1LMNA | |
| SCHEMBL12627087 | 0.79 | OPRD1 (0.51) | GAACYP2D6ALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095402-A9 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2009-06-11 | — | — | WO | disclosed |
| EP-1730147-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005095402-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2005-10-13 | — | — | WO | disclosed |