Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 7/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7173176 | 0.81 | ESR1 (0.36) | HCAR2ESR1ESR2PGRALDH1A1 | |
| Maleic Acid SCHEMBL4001893 | 0.78 | ALDH1A1 (0.41) | HCAR2HDAC3TNKSHDAC4HDAC1 | |
| SCHEMBL27890646 | 0.76 | LMNA (0.50) | HCAR2HDAC3TNKSHDAC4HDAC1 | |
| SCHEMBL28613781 | 0.76 | LMNA (0.50) | HCAR2HDAC3TNKSHDAC4HDAC1 | |
| Maleic Acid SCHEMBL3692041 | 0.74 | HCAR2 (0.45) | HCAR2ALDH1A1L3MBTL1 | |
| SCHEMBL179701 | 0.73 | CYP1A2 (0.49) | HCAR2HDAC3TNKSHDAC4HDAC1 | |
| SCHEMBL5162573 | 0.72 | TSHR (0.46) | ALDH1A1NPC1KDM4ESMN1; SMN2TDP1 | |
| SCHEMBL7998352 | 0.72 | LMNA (0.49) | HCAR2HDAC3TNKSHDAC4HDAC1 | |
| SCHEMBL10584305 | 0.72 | LMNA (0.49) | HCAR2HDAC3TNKSHDAC4HDAC1 | |
| Juarezic Acid SCHEMBL6858341 | 0.72 | HDAC3 (0.49) | HCAR2HDAC3TNKSHDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902810-B1 | THERMOPLASTIC MOULDED MATERIALS BASED ON POLYCARBONATES AND STYRENE/ACRYLONITRILE POLYMERS WHICH CONTAIN COPOLYMERS BASED ON ALKYL(METH)ACRYLATE TO IMPROVE THEIR PROPERTIES | BASF AG (DE) | 2003-01-22 | — | — | EP | disclosed |
| EP-0716100-B1 | Glazing for planes with light stability, chemical stability and heat distortion resistance | ROEHM GMBH (DE) | 1999-06-09 | — | — | EP | disclosed |
| EP-0902810-A1 | THERMOPLASTIC MOULDED MATERIALS BASED ON POLYCARBONATES AND STYRENE/ACRYLONITRILE POLYMERS WHICH CONTAIN COPOLYMERS BASED ON ALKYL(METH)ACRYLATE TO IMPROVE THEIR PROPERTIES | BASF AKTIENGESELLSCHAFT (DE) | 1999-03-24 | — | — | EP | disclosed |
| WO-1997045484-A1 | THERMOPLASTIC MOULDED MATERIALS BASED ON POLYCARBONATES AND STYRENE/ACRYLONITRILE POLYMERS WHICH CONTAIN COPOLYMERS BASED ON ALKYL(METH)ACRYLATE TO IMPROVE THEIR PROPERTIES | BASF AKTIENGESELLSCHAFT (DE) | 1997-12-04 | — | — | WO | disclosed |
| EP-0716100-A1 | Glazing for planes with improved light stability, improved chemical stability and improved heat distortion resistance | Röhm GmbH (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0667777-A1 | XANTHINE DERIVATIVES FOR USE AS DIURETICS | BOEHRINGER INGELHEIM INTERNATIONAL GmbH (DE) | 1995-08-23 | — | — | EP | disclosed |
| EP-0457147-B1 | Polymer compositions | ROEHM GMBH (DE) | 1995-06-14 | — | — | EP | disclosed |
| WO-1994011000-A1 | XANTHINE DERIVATIVES FOR USE AS DIURETICS | BOEHRINGER INGELHEIM KG (DE) | 1994-05-26 | — | — | WO | disclosed |
| EP-0457147-A1 | Polymer compositions | RÖHM GMBH (DE) | 1991-11-21 | — | — | EP | disclosed |