Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | CMA1 | P23946 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30527306 | 1.00 | MEN1 (0.67) | MEN1KMT2APOLBMAPTCYP2C9 | |
| SCHEMBL26357193 | 0.93 | KMT2A (0.58) | MEN1KMT2APOLBMAPTCYP2C9 | |
| SCHEMBL7247210 | 0.87 | CMA1 (0.55) | MEN1KMT2APOLBMAPTCYP2C9 | |
| SCHEMBL4003120 | 0.81 | GAA (0.66) | MEN1KMT2APOLBMAPTCYP2C9 | |
| SCHEMBL29234312 | 0.81 | SIGMAR1 (0.58) | MEN1KMT2AMAPTCMA1SIGMAR1 | |
| SCHEMBL30945865 | 0.81 | SIGMAR1 (0.58) | MEN1KMT2AMAPTCMA1SIGMAR1 | |
| SCHEMBL2191407 | 0.78 | KMT2A (0.56) | MEN1KMT2APOLBMAPTCYP2C9 | |
| SCHEMBL8799862 | 0.77 | KMT2A (0.60) | MEN1KMT2AMAPTCMA1SIGMAR1 | |
| SCHEMBL5545709 | 0.77 | CMA1 (0.56) | MEN1KMT2AMAPTCMA1SIGMAR1 | |
| SCHEMBL8711821 | 0.77 | POLB (0.68) | MEN1KMT2APOLBMAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303544-A1 | LMO2 PROTEIN INHIBITORS | UNIV OF OXFORD (GB) | 2023-09-28 | — | — | US | disclosed |
| US-20230303544-A1 | LMO2 PROTEIN INHIBITORS | UNIV OF OXFORD (GB) | 2023-09-28 | — | — | US | disclosed |
| US-20230303544-A1 | LMO2 PROTEIN INHIBITORS | UNIV OF OXFORD (GB) | 2023-09-28 | — | — | US | disclosed |
| EP-3548468-B1 | TRICYCLIC RHO KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-3548468-B1 | TRICYCLIC RHO KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-09-16 | — | — | EP | disclosed |
| US-10654860-B2 | Tricyclic rho kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-05-19 | — | — | US | disclosed |
| US-10654860-B2 | Tricyclic rho kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190276466-A1 | TRICYCLIC RHO KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-09-12 | — | — | US | disclosed |
| US-20190276466-A1 | TRICYCLIC RHO KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-09-12 | — | — | US | disclosed |
| WO-2009078992-A1 | LINEAR TRICYCLIC COMPOUNDS AS P38 KINASE INHIBITORS | AMGEN INC. (US) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303544-A1 | LMO2 PROTEIN INHIBITORS | LMNB2, LMNB1, TPX2 | MEN1 1792/4885KMT2A 3315/4885POLB 2249/4885 |
| US-10654860-B2 | Tricyclic rho kinase inhibitors | ROCK1, MYLK, ROCK2 | MEN1 878/4885KMT2A 2394/4885POLB 3690/4885 |
| US-20190276466-A1 | TRICYCLIC RHO KINASE INHIBITORS | ROCK1, MYLK, ROCK2 | MEN1 878/4885KMT2A 2394/4885POLB 3690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.