Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4010678 | 0.88 | HSD11B1 (0.45) | EPHX2HSD11B1SMN1; SMN2LMNA | |
| SCHEMBL4006571 | 0.87 | HSD11B1 (0.43) | HSD11B1SMN1; SMN2LMNA | |
| SCHEMBL4005701 | 0.86 | CXCR2 (0.36) | EPHX2CTSLCTSBCTSSHSD11B1 | |
| SCHEMBL4010821 | 0.84 | KMT2A (0.37) | EPHX2KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4010564 | 0.83 | EPHX2 (0.35) | EPHX2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL4292846 | 0.83 | EPHX2 (0.45) | EPHX2 | |
| SCHEMBL4001806 | 0.82 | ATM (0.44) | EPHX2CTSLCTSBCTSSHSD11B1 | |
| SCHEMBL4006938 | 0.82 | L3MBTL1 (0.39) | EPHX2CTSSKMT2AMEN1ALDH1A1 | |
| SCHEMBL4005536 | 0.81 | SMN1; SMN2 (0.43) | EPHX2KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4009267 | 0.81 | HSD11B1 (0.39) | EPHX2CTSSHSD11B1KMT2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |