Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4000824 | 0.86 | SLC6A9 (0.49) | SLC6A9ROCK2ROCK1NPC1RAB9A | |
| SCHEMBL4006834 | 0.85 | SLC6A9 (0.56) | SLC6A9ROCK2ROCK1NPC1RAB9A | |
| SCHEMBL4011286 | 0.82 | SLC6A9 (0.50) | SLC6A9TACR3SSTR4HDAC1HSD17B10 | |
| SCHEMBL1109553 | 0.79 | CTSL (0.51) | NPC1RAB9ACTDSP1CTSLCTSB | |
| SCHEMBL4010839 | 0.78 | SLC6A9 (0.51) | SLC6A9NPC1RAB9ATACR3SSTR4 | |
| SCHEMBL4003575 | 0.77 | ALDH1A1 (0.58) | SLC6A9ROCK2ROCK1NPC1RAB9A | |
| SCHEMBL10605790 | 0.77 | LMNA (0.51) | ROCK2ROCK1TACR3CTSLSSTR4 | |
| SCHEMBL9786501 | 0.76 | HDAC1 (0.49) | ROCK2ROCK1SSTR4HDAC1MEN1 | |
| SCHEMBL4006087 | 0.74 | SSTR4 (0.54) | SLC6A9NPC1RAB9ASSTR4HDAC1 | |
| SCHEMBL4007365 | 0.74 | SSTR4 (0.54) | SLC6A9NPC1RAB9ASSTR4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |