Sugi Predict

Sugi Predict / Compounds / SCHEMBL4007965

SCHEMBL4007965

SCHEMBL4007965

Nc1cc(C(=O)O)ccc1Cc1ccccc1C(=O)O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.61
▸ ALDH1A1 P00352 6/20 0.54
▸ KDM4E B2RXH2 5/20 0.54
▸ TDP1 Q9NUW8 1/20 0.54
▸ GAA P10253 4/20 0.50
▸ MAPT P10636 4/20 0.50
▸ RAB9A P51151 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ CYP2C9 P11712 1/20 0.48
▸ HIF1A Q16665 1/20 0.48
▸ POLB P06746 1/20 0.48
▸ HSD17B10 Q99714 2/20 0.46
▸ THRB P10828 2/20 0.46
▸ HPGD P15428 2/20 0.46
▸ CDC25B P30305 3/20 0.45
▸ CDC25A P30304 1/20 0.45
▸ FOLH1 Q04609 1/20 0.45
▸ CA1 P00915 1/20 0.43
▸ CA2 P00918 1/20 0.43
▸ CA9 Q16790 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23000227 0.87 ALDH1A1 (0.54) TSHRALDH1A1KDM4ETDP1GAA
SCHEMBL5808173 0.84 TSHR (0.56) TSHRALDH1A1KDM4EGAAMAPT
SCHEMBL16316852 0.81 TSHR (0.61) TSHRALDH1A1KDM4ECYP2C9HIF1A
SCHEMBL69352 0.80 TSHR (0.68) TSHRALDH1A1KDM4EGAAMAPT
SCHEMBL27994405 0.79 TSHR (0.55) TSHRALDH1A1KDM4ETDP1GAA
SCHEMBL28836287 0.79 TSHR (0.55) TSHRALDH1A1KDM4ETDP1GAA
SCHEMBL17938486 0.78 TSHR (0.66) TSHRALDH1A1KDM4EGAAMAPT
SCHEMBL28845431 0.77 TSHR (0.57) TSHRALDH1A1KDM4EGAAMAPT
SCHEMBL28831581 0.77 TSHR (0.57) TSHRALDH1A1KDM4ETDP1GAA
SCHEMBL14542167 0.77 TSHR (0.56) TSHRKDM4ECYP2C9HIF1APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025890-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES INC (US) 2024-01-25 — — US disclosed
US-20240025890-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES INC (US) 2024-01-25 — — US disclosed
US-20240025890-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES INC (US) 2024-01-25 — — US disclosed
US-11814376-B2 Hepatitis b core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2023-11-14 — — US disclosed
US-11814376-B2 Hepatitis b core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2023-11-14 — — US disclosed
US-11814376-B2 Hepatitis b core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2023-11-14 — — US disclosed
US-20230044112-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES, INC. (US) 2023-02-09 — — US disclosed
US-20230044112-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES, INC. (US) 2023-02-09 — — US disclosed
US-10968211-B2 Hepatitis B core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2021-04-06 — — US disclosed
US-10968211-B2 Hepatitis B core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2021-04-06 — — US disclosed
US-20080090805-A1 CB-1 MODULATING COMPOUNDS AND THEIR USE ACADIA PHARMACEUTICALS INC. (US) 2008-04-17 — — US disclosed
US-20080090805-A1 CB-1 MODULATING COMPOUNDS AND THEIR USE ACADIA PHARMACEUTICALS INC. (US) 2008-04-17 — — US disclosed
US-20080090805-A1 CB-1 MODULATING COMPOUNDS AND THEIR USE ACADIA PHARMACEUTICALS INC. (US) 2008-04-17 — — US disclosed
US-20070106074-A1 Iron catalyzed cross-coupling reactions of imidoyl derivatives ACADIA PHARMACEUTICALS 2007-05-10 — — US disclosed
US-20070105819-A1 CB-1 modulating compounds and their use ACADIA PHARMACEUTICALS, INC. 2007-05-10 — — US disclosed
US-20070105819-A1 CB-1 modulating compounds and their use ACADIA PHARMACEUTICALS, INC. 2007-05-10 — — US disclosed
US-20070105819-A1 CB-1 modulating compounds and their use ACADIA PHARMACEUTICALS, INC. 2007-05-10 — — US disclosed
WO-2007047737-A1 CB-1 MODULATING COMPOUNDS AND THEIR USE ACADIA PHARMACEUTICALS INC. (US) 2007-04-26 — — WO disclosed
WO-2007047737-A1 CB-1 MODULATING COMPOUNDS AND THEIR USE ACADIA PHARMACEUTICALS INC. (US) 2007-04-26 — — WO disclosed
WO-2007047776-A1 IRON CATALYZED CROSS-COUPLING REACTIONS OF IMIDOYL DERIVATIVES ACADIA PHARMACEUTICALS INC. (US) 2007-04-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070106074-A1 Iron catalyzed cross-coupling reactions of imidoyl derivatives SDHB, TFRC, SLC40A1 TSHR 2617/4885ALDH1A1 1576/4885KDM4E 1976/4885
US-20070105819-A1 CB-1 modulating compounds and their use CNR1, CNR2, FAAH TSHR 1641/4885ALDH1A1 888/4885KDM4E 2248/4885
US-20240025890-A1 HEPATITIS B CORE PROTEIN MODULATORS HAVCR2, FABP1, MAVS TSHR 2610/4885ALDH1A1 4316/4885KDM4E 2170/4885
US-20230044112-A1 HEPATITIS B CORE PROTEIN MODULATORS HAVCR2, FABP1, MAVS TSHR 2610/4885ALDH1A1 4316/4885KDM4E 2170/4885
US-10968211-B2 Hepatitis B core protein modulators HAVCR2, FABP1, MAVS TSHR 2610/4885ALDH1A1 4316/4885KDM4E 2170/4885
US-11814376-B2 Hepatitis b core protein modulators HAVCR2, FABP1, MAVS TSHR 2610/4885ALDH1A1 4316/4885KDM4E 2170/4885
US-20080090805-A1 CB-1 MODULATING COMPOUNDS AND THEIR USE CNR1, CNR2, FAAH TSHR 1641/4885ALDH1A1 888/4885KDM4E 2248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.