Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 8/20 | 0.52 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | F9 | P00740 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4010839 | 0.86 | SLC6A9 (0.51) | SLC6A9TACR3P2RX7SSTR4 | |
| SCHEMBL4011286 | 0.78 | SLC6A9 (0.50) | SLC6A9TACR3SSTR4 | |
| SCHEMBL4004238 | 0.76 | TACR3 (0.48) | SLC6A9TACR3ROCK2ROCK1MAPT | |
| SCHEMBL4006927 | 0.72 | SLC6A9 (0.49) | SLC6A9TACR3SSTR4ROCK2ROCK1 | |
| SCHEMBL4006834 | 0.71 | SLC6A9 (0.56) | SLC6A9ROCK2ROCK1MAPT | |
| SCHEMBL4003575 | 0.71 | ALDH1A1 (0.58) | SLC6A9ROCK2ROCK1 | |
| SCHEMBL19343472 | 0.70 | PHGDH (0.59) | SLC6A9 | |
| SCHEMBL4000824 | 0.70 | SLC6A9 (0.49) | SLC6A9SSTR4ROCK2ROCK1 | |
| SCHEMBL17188052 | 0.69 | HTR2A (0.50) | SLC6A9SSTR4ROCK2ROCK1 | |
| SCHEMBL24943684 | 0.69 | OPRM1 (0.41) | CHRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |