Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 3/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016181 | 0.85 | MEN1 (0.42) | NOD1MEN1KMT2ADPP4CASR | |
| SCHEMBL4014400 | 0.84 | ADORA2A (0.41) | MEN1KMT2ADPP4CASRPARP1 | |
| SCHEMBL4283981 | 0.79 | TPH1 (0.34) | DPP4CASRPARP1ADORA2BADORA1 | |
| SCHEMBL4016921 | 0.78 | ADORA2B (0.41) | NOD1PARP1ADORA3ADORA2BADORA1 | |
| SCHEMBL4293285 | 0.78 | BRD4 (0.39) | DPP4PARP1 | |
| SCHEMBL4285483 | 0.78 | MEN1 (0.54) | NOD1MEN1KMT2AKDM1A | |
| SCHEMBL4019325 | 0.77 | LMNA (0.42) | PARP1 | |
| SCHEMBL4291739 | 0.75 | KDM1A (0.60) | MEN1KMT2ABRDTKDM1A | |
| SCHEMBL4284310 | 0.74 | KDM1A (0.54) | NOD1MEN1KMT2ABRDTKDM1A | |
| SCHEMBL4295147 | 0.74 | MAOB (0.40) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009157938-A1 | A2B ADENOSINE RECEPTOR ANTAGONISTS FOR TREATING CANCER | CV THERAPEUTICS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009088518-A1 | A2B ADENOSINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CANCER | CV THERAPEUTICS, INC. (US) | 2009-07-16 | — | — | WO | disclosed |