Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.31 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
| ▸ | DRD4 | P21917 | 2/20 | 0.30 |
| ▸ | DRD3 | P35462 | 2/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756695 | 0.68 | HSD11B1 (0.39) | HSD11B1 | |
| SCHEMBL13746898 | 0.68 | HSD11B1 (0.39) | HSD11B1 | |
| SCHEMBL4755201 | 0.65 | HSD11B1 (0.38) | HSD11B1 | |
| SCHEMBL4755140 | 0.63 | HSD11B1 (0.38) | HSD11B1 | |
| SCHEMBL30429836 | 0.59 | PDK1 (0.59) | HSD11B1KCNH2CYP2C9 | |
| SCHEMBL16441196 | 0.58 | KIF11 (0.62) | KIF11PTPN5KCNH2 | |
| SCHEMBL1087536 | 0.58 | NOTUM (0.42) | KIF11 | |
| SCHEMBL14649680 | 0.58 | HRH3 (0.54) | HSD11B1KIF11KCNH2HRH3 | |
| SCHEMBL11524401 | 0.58 | HRH3 (0.54) | HSD11B1KIF11KCNH2HRH3 | |
| SCHEMBL11524397 | 0.58 | HRH3 (0.54) | HSD11B1KIF11KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100403-A1 | SUBSTITUTED ARYL PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |