Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.37 |
| ▸ | KDM5A | P29375 | 6/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023082 | 1.00 | ALDH1A1 (0.50) | ALDH1A1AGTR1ABCB11GP6LTB4R2 | |
| SCHEMBL22424763 | 0.95 | ALDH1A1 (0.44) | ALDH1A1KDM4CKDM5AKDM5CKDM5B | |
| SCHEMBL28892954 | 0.93 | PLA2G2A (0.44) | ALDH1A1KDM4CKDM5APLA2G2APLA2G5 | |
| SCHEMBL28892975 | 0.93 | PLA2G2A (0.44) | ALDH1A1KDM4CKDM5APLA2G2APLA2G5 | |
| SCHEMBL28893067 | 0.93 | PLA2G2A (0.44) | ALDH1A1KDM4CKDM5APLA2G2APLA2G5 | |
| SCHEMBL1654403 | 0.93 | PLA2G2A (0.44) | ALDH1A1KDM4CKDM5APLA2G2APLA2G5 | |
| SCHEMBL16499600 | 0.93 | PLA2G2A (0.44) | ALDH1A1KDM4CKDM5APLA2G2APLA2G5 | |
| SCHEMBL28893146 | 0.93 | PLA2G2A (0.44) | ALDH1A1KDM4CKDM5APLA2G2APLA2G5 | |
| SCHEMBL31589129 | 0.82 | CHRNB2 (0.33) | ALDH1A1KDM4CKDM5ACHRNB2CHRNB4 | |
| SCHEMBL14411541 | 0.82 | ALDH1A1 (0.38) | ALDH1A1CES2CES1PLA2G2APLA2G5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009098451-A2 | BIOMARKERS OF AMINOPEPTIDASE INHIBITION | CHROMA THERAPEUTICS LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |
| US-20080221184-A1 | Combined agents for treatment of glaucoma | SANKYO COMPANY LIMITED (JP) | 2008-09-11 | — | — | US | disclosed |
| US-20080119657-A1 | PHENYLTETRAZOLE COMPOUNDS | DIPHARMA S. P. A. (IT) | 2008-05-22 | — | — | US | disclosed |
| US-20080119657-A1 | PHENYLTETRAZOLE COMPOUNDS | DIPHARMA S. P. A. (IT) | 2008-05-22 | — | — | US | disclosed |
| US-7345072-B2 | Phenyltetrazole compounds | DIPHARMA S.P.A. (IT) | 2008-03-18 | — | — | US | disclosed |
| US-7345072-B2 | Phenyltetrazole compounds | DIPHARMA S.P.A. (IT) | 2008-03-18 | — | — | US | disclosed |
| US-7307096-B2 | Combined agents for treatment of glaucoma | SANKYO COMPANY, LIMITED (JP) | 2007-12-11 | — | — | US | disclosed |
| US-20070093540-A1 | PROCESS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTIC COMPOUNDS | DIPHARMA S.P.A. (IT) | 2007-04-26 | — | — | US | disclosed |
| US-20070093540-A1 | PROCESS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTIC COMPOUNDS | DIPHARMA S.P.A. (IT) | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119657-A1 | PHENYLTETRAZOLE COMPOUNDS | ACE, AGTR2, ACE2 | ALDH1A1 1607/4885AGTR1 4/4885ABCB11 1757/4885 |
| US-20070093540-A1 | PROCESS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTIC COMPOUNDS | AGTR2, AGTR1, ACE2 | ALDH1A1 2207/4885AGTR1 2/4885ABCB11 4043/4885 |
| US-20080221184-A1 | Combined agents for treatment of glaucoma | PTGIS, AGT, PTGIR | ALDH1A1 2387/4885AGTR1 17/4885ABCB11 1285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.