Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 6/20 | 0.50 |
| ▸ | CTSL | P07711 | 3/20 | 0.48 |
| ▸ | CTSB | P07858 | 3/20 | 0.48 |
| ▸ | CTSD | P07339 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | CTSK | P43235 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023208 | 1.00 | PIN1 (0.50) | PIN1CTSLCTSBCTSDCTSS | |
| SCHEMBL25219443 | 1.00 | PIN1 (0.50) | PIN1CTSLCTSBCTSDCTSS | |
| SCHEMBL13687944 | 0.89 | CTSK (0.48) | PIN1CTSLCTSBCTSDCTSS | |
| SCHEMBL21409319 | 0.88 | CTSK (0.44) | CTSSCTSKTSHRITGB3ITGA2B | |
| SCHEMBL21409318 | 0.88 | CTSK (0.44) | CTSSCTSKTSHRITGB3ITGA2B | |
| SCHEMBL3892487 | 0.87 | CTSK (0.45) | CTSSCTSKTSHRITGB3ITGA2B | |
| SCHEMBL3892481 | 0.87 | CTSK (0.45) | CTSSCTSKTSHRITGB3ITGA2B | |
| SCHEMBL25219487 | 0.87 | CTSS (0.50) | CTSLCTSBCTSDCTSSCTSK | |
| SCHEMBL7060009 | 0.87 | CTSS (0.50) | CTSLCTSBCTSDCTSSCTSK | |
| SCHEMBL6843347 | 0.87 | CTSS (0.50) | CTSLCTSBCTSDCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108117582-A | Big ring epoxy ketone peptides and preparation method thereof and medical usage | 浙江大学 | 2018-06-05 | — | — | CN | disclosed |
| US-7589115-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7589115-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7589115-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20080090819-A1 | DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-SULFONYLAMINO]-PROPIONAMIDE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-04-17 | — | — | US | disclosed |
| US-20080090819-A1 | DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-SULFONYLAMINO]-PROPIONAMIDE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-04-17 | — | — | US | disclosed |
| US-20080090819-A1 | DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-SULFONYLAMINO]-PROPIONAMIDE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-04-17 | — | — | US | disclosed |
| US-7345074-B2 | Derivatives of [6,7-dihydro-5H-imidazol[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-7345074-B2 | Derivatives of [6,7-dihydro-5H-imidazol[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-7345074-B2 | Derivatives of [6,7-dihydro-5H-imidazol[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-7304067-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304067-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| EP-1560830-B1 | DERIVATIVES OF [6, 7-DIHYDRO-5H-IMIDAZO[1,2 - A]IMIDAZOLE -3 -SULFONYLAMINO]-PROPIONAMIDE AND THEIR USE AS INHIBITORS UPON THE INTERACTION OF CAMS AND LEUKOINTEGRINS | BOEHRINGER INGELHEIM PHARMA (US) | 2006-10-25 | — | — | EP | disclosed |
| EP-1712553-A2 | Derivates of [6, 7-dihydro - 5H - imidazo[1,2- alpha]imidazole-3-sulfonylamino]-propionamide and their use as inhibitors upon the interaction of CAMS and leukointegrins | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| EP-1560830-A2 | DERIVATIVES OF [6, 7 - DIHYDRO - 5H - IMIDAZO [1,2 - A] IMIDAZOLE - 3 - SULFONYLAMINO]- PROPIONAMIDE AND THEIR USE AS INHIBITORS UPON THE INTERACTION OF CAMS AND LEUKOINTEGRINS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-08-10 | — | — | EP | disclosed |
| US-20050165027-A1 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-07-28 | — | — | US | disclosed |
| US-20050054703-A1 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-03-10 | — | — | US | disclosed |
| US-6844360-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-01-18 | — | — | US | disclosed |
| US-20040127534-A1 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-07-01 | — | — | US | disclosed |
| WO-2004041827-A2 | DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-α] IMIDAZOLE-3-SULFONYLAMINO]-PROPIONAMIDE AND THEIR USE AS INHIBITORS UPON THE INTERACTION OF CAMS AND LEUKO INTEGRINS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127534-A1 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide | ARG1, ARG2, HPGDS | PIN1 1849/4885CTSL 1522/4885CTSB 2823/4885 |
| US-20080090819-A1 | DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-SULFONYLAMINO]-PROPIONAMIDE | HPGDS, PTGIS, API5 | PIN1 1130/4885CTSL 747/4885CTSB 1577/4885 |
| US-20050054703-A1 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide | HPGDS, PTGIS, API5 | PIN1 1130/4885CTSL 747/4885CTSB 1577/4885 |
| US-20050165027-A1 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide | HPGDS, PTGIS, API5 | PIN1 1130/4885CTSL 747/4885CTSB 1577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.