Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 9/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.53 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4022761 | 1.00 | DHODH (1.00) | DHODHALOX15SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4025228 | 1.00 | DHODH (1.00) | DHODHALOX15SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL30338397 | 1.00 | DHODH (1.00) | DHODHALOX15SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL24727760 | 0.91 | DHODH (0.84) | DHODHALOX15SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4022932 | 0.89 | DHODH (0.80) | DHODHALOX15SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4254861 | 0.88 | DHODH (0.79) | DHODHALOX15SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL31120774 | 0.87 | DHODH (0.76) | DHODHALOX15SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4022138 | 0.86 | DHODH (0.75) | DHODHALOX15SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4023145 | 0.85 | DHODH (0.74) | DHODHALOX15SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4022078 | 0.85 | DHODH (0.74) | DHODHALOX15SMN1; SMN2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240245664-A1 | METHODS OF USING USP15 INHIBITORS | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2024-07-25 | — | — | US | claimed |
| WO-2023039405-A1 | METHODS OF USING USP15 INHIBITORS | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2023-03-16 | — | — | WO | claimed |
| US-20220280513-A1 | ENHANCING THE ANTIVIRAL EFFICACY OF RNA VIRUS INHIBITION BY COMBINATION WITH MODULATORS OF PYRIMIDINE METABOLISM | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2022-09-08 | — | — | US | claimed |
| WO-2022167402-A1 | METHODS OF THERAPY COMPRISING ADMINISTERING A THERAPEUTICALLY EFFECTIVE COMBINATION COMPRISING A DHODH INHIBITOR AND AN IDH INHIBITOR | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2022-08-11 | — | — | WO | claimed |
| EP-1646610-B1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2009-07-22 | — | — | EP | claimed |
| US-7419997-B2 | Tetrahydrocarbazole derivatives and their pharmaceutical use | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-02 | — | — | US | claimed |
| US-20060148857-A1 | Tetrahydrocarbazole derivatives and their pharmaceutical use | SMITHKLINE BEECHAM CORPORATION | 2006-07-06 | — | — | US | claimed |
| US-12521397-B2 | Nucleotide analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-01-13 | — | — | US | disclosed |
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| US-12350274-B2 | Nucleotide analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-07-08 | — | — | US | disclosed |
| WO-2024220843-A1 | TECHNOLOGIES TARGETING CELL STATES | AURON THERAPEUTICS, INC. (US) | 2024-10-24 | — | — | WO | disclosed |
| US-20240325373-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD47-SIRPA THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2024-10-03 | — | — | US | disclosed |
| US-20240245664-A1 | METHODS OF USING USP15 INHIBITORS | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2024-07-25 | — | — | US | disclosed |
| US-20090170906-A1 | HCV INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-07-02 | — | — | US | disclosed |
| US-7419997-B2 | Tetrahydrocarbazole derivatives and their pharmaceutical use | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-02 | — | — | US | disclosed |
| US-7419997-B2 | Tetrahydrocarbazole derivatives and their pharmaceutical use | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-02 | — | — | US | disclosed |
| US-7419997-B2 | Tetrahydrocarbazole derivatives and their pharmaceutical use | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-02 | — | — | US | disclosed |
| US-20060148857-A1 | Tetrahydrocarbazole derivatives and their pharmaceutical use | SMITHKLINE BEECHAM CORPORATION | 2006-07-06 | — | — | US | disclosed |
| EP-1646610-A1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SmithKline Beecham Corporation (US) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005005386-A1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170906-A1 | HCV INHIBITORS | HAVCR2, MAVS, EIF2AK2 | DHODH 103/4885ALOX15 1407/4885SMN1; SMN2 4443/4885 |
| US-20240325373-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD47-SIRPA THERAPEUTIC AGENT | DHODH, CD47, IDH1 | DHODH 1/4885ALOX15 2778/4885SMN1; SMN2 3497/4885 |
| US-12350274-B2 | Nucleotide analogs | NUDT1, DUT, DPYD | DHODH 178/4885ALOX15 3316/4885SMN1; SMN2 3595/4885 |
| US-20220280513-A1 | ENHANCING THE ANTIVIRAL EFFICACY OF RNA VIRUS INHIBITION BY COMBINATION WITH MODULATORS OF PYRIMIDINE METABOLISM | EIF2AK2, RNGTT, RNMT | DHODH 167/4885ALOX15 2468/4885SMN1; SMN2 1371/4885 |
| US-20060148857-A1 | Tetrahydrocarbazole derivatives and their pharmaceutical use | HMBS, UGT2B17, TPMT | DHODH 62/4885ALOX15 939/4885SMN1; SMN2 4735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.