Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27918170 | 0.90 | GPBAR1 (0.63) | GPBAR1GAATSHRKMT2AMEN1 | |
| SCHEMBL2471876 | 0.89 | GPBAR1 (0.62) | GPBAR1GAATSHRKMT2AMEN1 | |
| SCHEMBL4333884 | 0.85 | GPBAR1 (0.60) | GPBAR1GAATSHRKMT2AMEN1 | |
| SCHEMBL4332194 | 0.85 | KMT2A (0.49) | GPBAR1GAATSHRKMT2AMEN1 | |
| SCHEMBL13734171 | 0.85 | GPBAR1 (0.58) | GPBAR1GAATSHRKMT2AMEN1 | |
| SCHEMBL2472816 | 0.84 | GPBAR1 (0.57) | GPBAR1GAATSHRKMT2AMEN1 | |
| SCHEMBL316093 | 0.83 | KMT2A (0.76) | GPBAR1GAATSHRKMT2AMEN1 | |
| SCHEMBL13733599 | 0.83 | LMNA (0.49) | GPBAR1GAATSHRKMT2AMEN1 | |
| SCHEMBL1931107 | 0.83 | GPBAR1 (0.66) | GPBAR1GAATSHRKMT2AMEN1 | |
| SCHEMBL1776068 | 0.83 | GPBAR1 (0.59) | GPBAR1GAATSHRHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259620-A1 | ALDEHYDE DEHYDROGENASE INHIBITORS AND THEIR THERAPEUTIC USE | Cancer Research Technology Limited (GB) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022123039-A1 | ALDEHYDE DEHYDROGENASE INHIBITORS AND THEIR THERAPEUTIC USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-06-16 | — | — | WO | disclosed |
| EP-2699566-B1 | PHENYL-ISOXAZOL DERIVATIVES AND PREPARATION PROCESS THEREOF | IL-YANG PHARM CO LTD (KR) | 2017-02-22 | — | — | EP | disclosed |
| CN-103313982-B | Phenyl-isoxazole derivatives and process for the preparation thereof | IL-YANG PHARM. CO.,LTD. (KR) | 2016-02-03 | — | — | CN | disclosed |
| US-9132126-B2 | Phenyl-isoxazole derivatives and preparation process thereof | IL-YANG PHARM. CO., LTD. (KR) | 2015-09-15 | — | — | US | disclosed |
| EP-2767536-B1 | Isoxazolo-pyridine derivatives | HOFFMANN LA ROCHE (CH) | 2015-09-02 | — | — | EP | disclosed |
| EP-2227467-B1 | ISOXAZOLO-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-12-31 | — | — | EP | disclosed |
| EP-2767536-A1 | ISOXAZOLO-PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2014-08-20 | — | — | EP | disclosed |
| EP-2699566-A1 | PHENYL-ISOXAZOL DERIVATIVES AND PREPARATION PROCESS THEREOF | Il-Yang Pharm. Co., Ltd. (KR) | 2014-02-26 | — | — | EP | disclosed |
| US-20140031364-A1 | PHENYL-ISOXAZOL DERIVATIVES AND PREPARATION PROCESS THEREOF | IL-YANG PHARM. CO., LTD. (KR) | 2014-01-30 | — | — | US | disclosed |
| EP-1937674-A1 | ISOXAZOLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| US-7378435-B2 | Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-27 | — | — | US | disclosed |
| WO-2007042420-A1 | ISOXAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-19 | — | — | WO | disclosed |
| US-20070082936-A1 | Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives | HOFFMANN-LA ROCHE INC. | 2007-04-12 | — | — | US | disclosed |
| US-6680319-B2 | TREATMENT OF OBSTRUCTIVE SYNDROMES OF THE LOWER URINARY TRACT, INCLUDING BENIGN PROSTATIC HYPERPLASIA, TREATMENT OF LOWER URINARY TRACT SYMPTOMS | RECORDATI S.A. (CH) | 2004-01-20 | — | — | US | disclosed |
| EP-1226131-B1 | ISOXAZOLECARBOXAMIDE DERIVATIVES | RECORDATI CHEM PHARM (IT) | 2003-12-17 | — | — | EP | disclosed |
| US-20020161012-A1 | Isoxazolecarboxamide derivatives | RECORDATI, S.A., CHEMICAL AND PHARMACEUTICAL COMPANY | 2002-10-31 | — | — | US | disclosed |
| EP-1226131-A2 | ISOXAZOLECARBOXAMIDE DERIVATIVES | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 2002-07-31 | — | — | EP | disclosed |
| US-6365591-B1 | FOR THERAPY OF OBSTRUCTIVE SYNDROMES OF THE LOWER URINARY TRACT, INCLUDING BENIGN PROSTATIC HYPERPLASIA (BPH), AND IN THE TREATMENT OF LOWER URINARY TRACT SYMPTOMS (LUTS) AND NEUROGENIC LOWER URINARY TRACT DYSFUNCTION (NLUTD) | RECORDATI, S.A., CHEMICAL AND PHARMACUETICALS COMPANY (CH) | 2002-04-02 | — | — | US | disclosed |
| WO-2001029015-A2 | ISOXAZOLECARBOXAMIDE DERIVATIVES AS ALPHA1-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 2001-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161012-A1 | Isoxazolecarboxamide derivatives | ADRA1D, NMUR1, NMUR2 | GPBAR1 703/4885GAA 3666/4885TSHR 2444/4885 |
| US-20140031364-A1 | PHENYL-ISOXAZOL DERIVATIVES AND PREPARATION PROCESS THEREOF | PIR, ALPL, PIGS | GPBAR1 4105/4885GAA 477/4885TSHR 3611/4885 |
| US-20070082936-A1 | Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives | GABRA5, GABRA4, CHRNA5 | GPBAR1 244/4885GAA 1212/4885TSHR 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.