Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
| ▸ | TKT | P29401 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336991 | 0.83 | PTGS2 (0.31) | PTGS2 | |
| SCHEMBL15488276 | 0.78 | CYP3A4 (0.30) | — | |
| SCHEMBL1456734 | 0.76 | MAPT (0.38) | — | |
| SCHEMBL28210197 | 0.75 | TRPV4 (0.32) | TRPV4PTGS2PTGS1AR | |
| SCHEMBL14120675 | 0.75 | NPC1 (0.31) | — | |
| SCHEMBL3883160 | 0.75 | DGAT1 (0.37) | — | |
| SCHEMBL7003724 | 0.75 | PTGS1 (0.30) | PTGS2PTGS1 | |
| SCHEMBL7792042 | 0.74 | LMNA (0.41) | — | |
| SCHEMBL4483092 | 0.73 | RAB9A (0.39) | TRPV3 | |
| SCHEMBL5641626 | 0.72 | KCNH2 (0.35) | KCNH2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4038064-B1 | N-SUBSTUTUTED-6-OXO-1,6-DIHYDROPYRIMIDINE-2-YL DERIVATIVES AS INHIBITORS OF THE HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE UK NO 5 LTD (GB) | 2024-02-21 | — | — | EP | disclosed |
| US-20220409619-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2022-12-29 | — | — | US | disclosed |
| EP-4038064-A1 | N-SUBSTUTUTED-6-OXO-1,6-DIHYDROPYRIMIDINE-2-YL DERIVATIVES AS INHIBITORS OF THE HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV Healthcare UK (No.5) Limited (GB) | 2022-08-10 | — | — | EP | disclosed |
| CN-113292502-A | Novel 4-aminopyridine and 6-aminopyrimidine carboxylates as herbicides | 美国陶氏益农公司 | 2021-08-24 | — | — | CN | disclosed |
| WO-2021064570-A1 | N-SUBSTUTUTED-6-OXO-1,6-DIHYDROPYRIMIDINE-2-YL DERIVATIVES AS INHIBITORS OF THE HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV Healthcare UK (No.5) Limited (GB) | 2021-04-08 | — | — | WO | disclosed |
| US-10765114-B2 | 4-amino-6-(pyridyl and 2-substitutedphenyl)-picolinates and 6-amino-2-(pyridyl and 2-substitutedphenyl)-pyrimidine-4-carboxylates and their use as herbicides | DOW AGROSCIENCES LLC (US) | 2020-09-08 | — | — | US | disclosed |
| EP-2967057-B1 | NOVEL 4-AMINOPYRIDINE AND 6-AMINOPYRIMIDINE CARBOXYLATES AS HERBICIDES | DOW AGROSCIENCES LLC (US) | 2018-11-21 | — | — | EP | disclosed |
| US-9695170-B2 | Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase | FIBROGEN, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| EP-2670750-B1 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR | FIBROGEN INC (US) | 2016-09-14 | — | — | EP | disclosed |
| US-20160159796-A1 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE | FIBROGEN, INC. | 2016-06-09 | — | — | US | disclosed |
| EP-1366043-B1 | 2-HETEROARYL-3,4-DIHYDRO-2H-PYRROLE DERIVATIVES AND THE USE THEREOF AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2007-06-20 | — | — | EP | disclosed |
| US-7186722-B2 | 2-heteroaryl-3,4-dihydro-2h-pyrrole derivatives and the use thereof as pesticides | BAYER CROPSCIENCE AG (DE) | 2007-03-06 | — | — | US | disclosed |
| US-7179806-B2 | Δ1-pyrrolines used as pesticides | BAYER CROPSCIENCE AG (DE) | 2007-02-20 | — | — | US | disclosed |
| EP-1347957-B1 | DELTA 1-PYRROLINES USED AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2005-09-07 | — | — | EP | disclosed |
| US-20040116477-A1 | 2-Heteroaryl-3,4-dihydro-2h-pyrrole derivatives and the use thereof as pesticides | BAYER CROPSCIENCE AG (DE) | 2004-06-17 | — | — | US | disclosed |
| US-20040082586-A1 | Delta 1-pyrrolines used as pesticides | BAYER CROPSCIENCE AG (DE) | 2004-04-29 | — | — | US | disclosed |
| EP-1366043-A1 | 2-HETEROARYL-3,4-DIHYDRO-2H-PYRROLE DERIVATIVES AND THE USE THEREOF AS PESTICIDES | Bayer CropScience AG (DE) | 2003-12-03 | — | — | EP | disclosed |
| EP-1347957-A1 | DELTA 1-PYRROLINES USED AS PESTICIDES | Bayer CropScience AG (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002064588-A1 | 2-HETEROARYL-3,4-DIHYDRO-2H-PYRROLE DERIVATIVES AND THE USE THEREOF AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2002-08-22 | — | — | WO | disclosed |
| WO-2002046151-A1 | DELTA 1-PYRROLINES USED AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10765114-B2 | 4-amino-6-(pyridyl and 2-substitutedphenyl)-picolinates and 6-amino-2-(pyridyl and 2-substitutedphenyl)-pyrimidine-4-carboxylates and their use as herbicides | DDT, P2RX6, PLPBP | TRPV4 1441/4885PTGS2 1649/4885PTGS1 2663/4885 |
| US-20220409619-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | EIF2AK2, POLR2E, POLR2H | TRPV4 4744/4885PTGS2 2899/4885PTGS1 1432/4885 |
| US-20040082586-A1 | Delta 1-pyrrolines used as pesticides | DDT, CHRM1, PRMT1 | TRPV4 3130/4885PTGS2 2533/4885PTGS1 1370/4885 |
| US-20160159796-A1 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE | HIF1AN, HIF1A, EGLN2 | TRPV4 4319/4885PTGS2 312/4885PTGS1 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.