Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.32 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043268 | 0.91 | PKN1 (0.36) | TGFBR1PKN1PKN2JAK2GRM4 | |
| SCHEMBL4032967 | 0.90 | SMN1; SMN2 (0.41) | LMNATGFBR1PDE5AKMT2AGSK3B | |
| SCHEMBL4035502 | 0.86 | TUBB4A (0.39) | LMNAJAK2PDE5ATUBB4ATUBB | |
| SCHEMBL4036370 | 0.85 | PARP1 (0.37) | TGFBR1PKN1PKN2JAK2PDE5A | |
| SCHEMBL4033192 | 0.85 | PKN1 (0.38) | PKN1PKN2JAK2PDE5ATUBB4A | |
| SCHEMBL4035489 | 0.83 | SLC6A4 (0.43) | LMNATGFBR1TGFBR2KMT2APARP1 | |
| SCHEMBL4036538 | 0.83 | JAK2 (0.48) | LMNATGFBR1PKN1PKN2JAK2 | |
| SCHEMBL4033989 | 0.82 | LMNA (0.39) | LMNATGFBR1PKN1PKN2JAK2 | |
| SCHEMBL4033058 | 0.82 | TYMS (0.37) | TGFBR1PKN1PKN2JAK2TGFBR2 | |
| SCHEMBL4036827 | 0.82 | KDM4E (0.43) | TGFBR1GRM4TGFBR2TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |