Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 5/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | STK3 | Q13188 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035502 | 0.91 | TUBB4A (0.39) | PARP1PARP2PDE5AJAK2KMT2A | |
| SCHEMBL4035489 | 0.88 | SLC6A4 (0.43) | CHEK2PARP1KMT2AMEN1 | |
| SCHEMBL4032967 | 0.88 | SMN1; SMN2 (0.41) | PDE5AKMT2AMEN1 | |
| SCHEMBL4034008 | 0.85 | LMNA (0.37) | PKN1PKN2PARP1PDE5AJAK2 | |
| SCHEMBL4039619 | 0.84 | MAPT (0.46) | PARP1TYMSKMT2AMEN1 | |
| SCHEMBL4036370 | 0.84 | PARP1 (0.37) | PKN1PKN2PLK4MAPK13DYRK3 | |
| SCHEMBL4033284 | 0.83 | PTGS1 (0.37) | PARP1PARP2PDE5AJAK2KCNMA1 | |
| SCHEMBL4033058 | 0.83 | TYMS (0.37) | PKN1PKN2JAK2TYMSKMT2A | |
| SCHEMBL4035517 | 0.83 | TYMS (0.37) | PKN1PKN2RPS6KB1MAPK14JAK2 | |
| SCHEMBL4043268 | 0.83 | PKN1 (0.36) | PKN1PKN2PARP1JAK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |