Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4024930 | 0.86 | ERCC1 (0.50) | ERCC1FEN1ERCC4HSD17B10HDAC1 | |
| SCHEMBL4024935 | 0.86 | ERCC1 (0.50) | ERCC1FEN1ERCC4HSD17B10HDAC1 | |
| SCHEMBL4028795 | 0.82 | ERCC1 (0.39) | ERCC1FEN1ERCC4MAPK1L3MBTL1 | |
| SCHEMBL4028019 | 0.80 | FEN1 (0.39) | ERCC1FEN1ERCC4HSD17B10MAPK1 | |
| SCHEMBL4026962 | 0.78 | F2 (0.39) | KDM4E | |
| SCHEMBL4027808 | 0.77 | DHFR (0.31) | DHFR | |
| SCHEMBL4027815 | 0.77 | DHFR (0.31) | DHFR | |
| SCHEMBL4031044 | 0.76 | NTRK1 (0.41) | ERCC1FEN1ERCC4HSD17B10HTT | |
| SCHEMBL4027166 | 0.76 | MEN1 (0.37) | ERCC1FEN1ERCC4HTTMAPK8 | |
| SCHEMBL4028369 | 0.76 | MEN1 (0.43) | ERCC1FEN1ERCC4HTTMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-B1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-01-07 | — | — | EP | claimed |