Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 9/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 6/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032604 | 0.69 | ALDH1A1 (0.52) | PRKAA2CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL27964887 | 0.64 | SLC6A7 (0.62) | PRKAA2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7958924 | 0.63 | S1PR2 (0.55) | HTTPARP10PARP14PARP1PRKAA2 | |
| SCHEMBL5635838 | 0.62 | LMNA (0.45) | MEN1KMT2AATM | |
| SCHEMBL1222295 | 0.62 | RAB9A (0.58) | HTTPARP10PARP14PARP1PRKAA2 | |
| SCHEMBL912218 | 0.62 | MGLL (0.56) | PRKAA2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL19791782 | 0.62 | KMT2A (0.51) | PARP10MEN1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL912776 | 0.62 | SLC6A7 (0.57) | MEN1KMT2ANPC1 | |
| SCHEMBL30600007 | 0.61 | HTT (0.62) | HTTPARP10PARP14MEN1KMT2A | |
| SCHEMBL15949260 | 0.61 | MGLL (0.67) | HTTPARP10PARP14MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |