Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | CTSD | P07339 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048343 | 0.89 | NPC1 (0.42) | SRCZAP70SYKNPC1RAB9A | |
| SCHEMBL4036701 | 0.78 | HTT (0.36) | MEN1KMT2A | |
| SCHEMBL4038860 | 0.65 | SRC (0.52) | SRCZAP70SYKCDK4CDK2 | |
| SCHEMBL4039114 | 0.65 | SRC (0.56) | SRCZAP70SYKCDK4CDK2 | |
| SCHEMBL788369 | 0.60 | DPP4 (0.39) | KDM1ADPP4MEN1KMT2APHGDH | |
| SCHEMBL679095 | 0.59 | ALDH1A1 (0.50) | RAB9AKDM1ADPP4HDAC3HDAC1 | |
| SCHEMBL5782136 | 0.59 | ALDH1A1 (0.58) | RAB9AKDM1AHDAC3HDAC1HDAC2 | |
| SCHEMBL8333311 | 0.59 | CYP11B1 (0.55) | MEN1KMT2A | |
| SCHEMBL130736 | 0.58 | L3MBTL1 (0.45) | RAB9AKDM1ADPP4HDAC3HDAC1 | |
| SCHEMBL30448494 | 0.58 | L3MBTL1 (0.45) | RAB9AKDM1ADPP4HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |