Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.39 |
| ▸ | CCR1 | P32246 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038362 | 0.85 | KMT2A (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL3927072 | 0.83 | ATAD2 (0.41) | ATAD2FAAHCCR1HDAC3HDAC4 | |
| SCHEMBL3916138 | 0.81 | PKM (0.39) | GAAALDH1A1MAPTTDP1KMT2A | |
| SCHEMBL4036735 | 0.78 | MAPT (0.43) | FAAHGAAHTTKDM4EALDH1A1 | |
| SCHEMBL3915970 | 0.77 | KMT2A (0.45) | GAAHTTNPSR1KDM4EALDH1A1 | |
| SCHEMBL4041475 | 0.77 | MMP2 (0.39) | GAAHTTALDH1A1MAPTKMT2A | |
| SCHEMBL3925373 | 0.76 | KDM4E (0.35) | ATAD2CCR1GAAKDM4EALDH1A1 | |
| SCHEMBL1800410 | 0.76 | OPRM1 (0.32) | HDAC8HTTALDH1A1MAPT | |
| SCHEMBL3926295 | 0.75 | FNTA (0.37) | ATAD2FAAHKDM4EALDH1A1KMT2A | |
| SCHEMBL2940210 | 0.75 | ITGB3 (0.36) | HDAC8MAPK1HTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |