Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043492 | 0.88 | VNN1 (0.39) | MMP8VNN1ACEREN | |
| SCHEMBL4044987 | 0.85 | MMP8 (0.51) | MMP8ERAP2ERAP1LNPEP | |
| SCHEMBL4040963 | 0.82 | REN (0.47) | MMP8REN | |
| SCHEMBL3936972 | 0.82 | REN (0.47) | MMP8REN | |
| SCHEMBL4039170 | 0.81 | HPGD (0.41) | MMP8ACE | |
| SCHEMBL4039656 | 0.80 | HDAC1 (0.42) | — | |
| SCHEMBL4342649 | 0.77 | SMN1; SMN2 (0.52) | — | |
| SCHEMBL4045052 | 0.75 | LMNA (0.46) | BCHE | |
| SCHEMBL4040058 | 0.74 | ALDH1A1 (0.45) | — | |
| SCHEMBL4042449 | 0.74 | SMN1; SMN2 (0.40) | CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001911-B2 | Fused cyclic modulators of nuclear hormone receptor function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-21 | — | — | US | claimed |
| EP-1463728-B1 | FUSED CYCLIC MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-01-14 | — | — | EP | disclosed |
| US-7001911-B2 | Fused cyclic modulators of nuclear hormone receptor function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-21 | — | — | US | disclosed |