SCHEMBL4042449

SCHEMBL4042449

NC(=O)[C@@H](C[C@@H](O)[CH]Cc1ccccc1)C(=O)NC1CCC(O)CC1

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.40
MFN2 O95140 1/20 0.39
TSHR P16473 1/20 0.37
TDP1 Q9NUW8 1/20 0.36
BRD4 O60885 2/20 0.36
EPHX2 P34913 3/20 0.35
SMYD3 Q9H7B4 1/20 0.35
CTSD P07339 1/20 0.35
ALDH1A1 P00352 2/20 0.34
EPHX1 P07099 1/20 0.34
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4042586 0.88 CTSD (0.41) SMN1; SMN2TSHRTDP1BRD4EPHX2
SCHEMBL4044687 0.86 SMN1; SMN2 (0.40) SMN1; SMN2ALDH1A1
SCHEMBL4042396 0.80 HPGD (0.45) SMN1; SMN2TSHREPHX2ALDH1A1
SCHEMBL4044987 0.77 MMP8 (0.51) ALDH1A1GAA
SCHEMBL4039656 0.77 HDAC1 (0.42) EPHX2ALDH1A1GAA
SCHEMBL27640144 0.75 SMN1; SMN2 (0.50) SMN1; SMN2TSHRTDP1EPHX2ALDH1A1
SCHEMBL4041195 0.74 MMP1 (0.41) CTSD
SCHEMBL4040963 0.73 REN (0.47) ALDH1A1
SCHEMBL3936972 0.73 REN (0.47) ALDH1A1
SCHEMBL4045052 0.73 LMNA (0.46) SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2052039-A1 COMPOSITIONS FOR POROUS MEMBRANES AND RECORDING MEDIA FUJIFILM Manufacturing Europe B.V. (NL) 2009-04-29 EP disclosed
EP-2051860-A1 POROUS MEMBRANES AND RECORDING MEDIA COMPRISING SAME Fuji Film Manufacturing Europe B.V. (NL) 2009-04-29 EP disclosed
EP-2051861-A1 POROUS MEMBRANE AND RECORDING MEDIA COMPRISING SAME FUJIFILM Manufacturing Europe B.V. (NL) 2009-04-29 EP disclosed
WO-2008016303-A1 POROUS MEMBRANE AND RECORDING MEDIA COMPRISING SAME FUJIFILM MANUFACTURING EUROPE B.V. (NL) 2008-02-07 WO disclosed
WO-2008016301-A1 POROUS MEMBRANES AND RECORDING MEDIA COMPRISING SAME FUJIFILM MANUFACTURING EUROPE B.V. (NL) 2008-02-07 WO disclosed
WO-2008016302-A1 COMPOSITIONS FOR POROUS MEMBRANES AND RECORDING MEDIA FUJIFILM MANUFACTURING EUROPE B.V. (NL) 2008-02-07 WO disclosed
EP-1861259-A1 METHOD OF MAKING MICROPOROUS MEMBRANES AND IMAGE RECORDING MATERIALS COMPRISING THE SAME FUJIFILM Manufacturing Europe B.V. (NL) 2007-12-05 EP disclosed
WO-2006101390-A1 METHOD OF MAKING MICROPOROUS MEMBRANES AND IMAGE RECORDING MATERIALS COMPRISING THE SAME FUJIFILM MANUFACTURING EUROPE B.V. (NL) 2006-09-28 WO disclosed
EP-1651592-A2 NOVEL DIBENZO[B,F]OXEPINE-10-CARBOXAMIDES AND PHARMACEUTICAL USES THEREOF Novartis AG (CH) 2006-05-03 EP disclosed
WO-2005014517-A2 NOVEL DIBENZO[B,F]OXEPINE-10-CARBOXAMIDES AND PHARMACEUTICAL USES THEREOF NOVARTIS AG (CH) 2005-02-17 WO disclosed