Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039656 | 0.92 | HDAC1 (0.42) | LMNAHTTPOLBTAAR1MAPT | |
| SCHEMBL4043128 | 0.88 | PKM (0.48) | LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL4040058 | 0.83 | ALDH1A1 (0.45) | SMN1; SMN2POLBKMT2A | |
| SCHEMBL4046147 | 0.80 | TSHR (0.44) | HTTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL4044987 | 0.79 | MMP8 (0.51) | KMT2A | |
| SCHEMBL4042233 | 0.77 | PKM (0.48) | SMN1; SMN2HPGDKMT2ANPSR1 | |
| SCHEMBL4342649 | 0.76 | SMN1; SMN2 (0.52) | LMNAHTTSMN1; SMN2POLBMAPT | |
| SCHEMBL4039621 | 0.76 | CCNA2 (0.46) | SMN1; SMN2JAK2ATM | |
| SCHEMBL4041195 | 0.75 | MMP1 (0.41) | BCHE | |
| SCHEMBL4040963 | 0.74 | REN (0.47) | LMNAHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436291-B1 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA SA (FR) | 2009-01-14 | — | — | EP | disclosed |