SCHEMBL4042946

SCHEMBL4042946

COC1CCCCC1=NO

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
KDM4E B2RXH2 1/20 0.37
USP2 O75604 1/20 0.33
LMNA P02545 1/20 0.33
POLB P06746 1/20 0.33
TSHR P16473 1/20 0.31
CASP1 P29466 1/20 0.31
AKR1C3 P42330 1/20 0.31
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5912747 1.00 ALDH1A1 (0.37) ALDH1A1KDM4EUSP2LMNAPOLB
SCHEMBL4042945 1.00 ALDH1A1 (0.37) ALDH1A1KDM4EUSP2LMNAPOLB
SCHEMBL5912720 0.98 ALDH1A1 (0.36) ALDH1A1KDM4EUSP2LMNAPOLB
SCHEMBL5912761 0.98 ALDH1A1 (0.36) ALDH1A1KDM4EUSP2LMNAPOLB
SCHEMBL5912156 0.98 ALDH1A1 (0.36) ALDH1A1KDM4EUSP2LMNAPOLB
SCHEMBL5912868 0.98 ALDH1A1 (0.36) ALDH1A1KDM4EUSP2LMNAPOLB
SCHEMBL5912744 0.98 ALDH1A1 (0.36) ALDH1A1KDM4EUSP2LMNAPOLB
SCHEMBL5912200 0.98 ALDH1A1 (0.36) ALDH1A1KDM4EUSP2LMNAPOLB
SCHEMBL5912740 0.98 ALDH1A1 (0.36) ALDH1A1KDM4EUSP2LMNAPOLB
SCHEMBL5912098 0.98 ALDH1A1 (0.36) ALDH1A1KDM4EUSP2LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060173205-A1 Process for producing w-cyanoaldehyde compound UBE INDUSTRIES, LTD. (JP) 2006-08-03 US claimed
US-20260001838-A1 NANOMATERIALS GUIDE THERAPEUTICS LLC (US) 2026-01-01 US disclosed
US-20250387509-A1 NANOMATERIALS COMPRISING A BIODEGRADABLE FEATURE BEAM THERAPEUTICS INC (US) 2025-12-25 US disclosed
US-12435035-B2 Nanomaterials GUIDE THERAPEUTICS, LLC (US) 2025-10-07 US disclosed
WO-2025104695-A1 IONIZABLE CATIONIC LIPIDS AND LIPID NANOPARTICLES THEREOF Corti Therapeutics Pte. Ltd. (SG) 2025-05-22 WO disclosed
US-12268753-B2 Nanomaterials comprising a biodegradable feature BEAM THERAPEUTICS INC. (US) 2025-04-08 US disclosed
CN-115175894-B Nanomaterial for the preparation of a nanoparticle 盖德治疗有限责任公司 2024-09-06 CN disclosed
EP-4281080-A1 NANOMATERIALS COMPRISING A BIODEGRADABLE FEATURE Beam Therapeutics Inc. (US) 2023-11-29 EP disclosed
EP-4262819-A1 NANOMATERIALS COMPRISING ESTER-LINKED ACETALS Beam Therapeutics Inc. (US) 2023-10-25 EP disclosed
US-20230331657-A1 NANOMATERIALS COMPRISING ESTER-LINKED ACETALS BEAM THERAPEUTICS INC. 2023-10-19 US disclosed
EP-1409468-B9 GUANIDINOBENZAMIDES AS MC4-R AGONISTS NOVARTIS VACCINES & DIAGNOSTIC (US) 2009-07-29 EP disclosed
EP-1409468-B1 GUANIDINOBENZAMIDES AS MC4-R AGONISTS NOVARTIS VACCINES & DIAGNOSTIC (US) 2008-11-12 EP disclosed
US-20060173205-A1 Process for producing w-cyanoaldehyde compound UBE INDUSTRIES, LTD. (JP) 2006-08-03 US disclosed
US-6995269-B2 Guanidinobenzamides CHIRON CORPORATION (US) 2006-02-07 US disclosed
EP-1409468-A2 GUANIDINOBENZAMIDES AS MC4-R AGONISTS CHIRON CORPORATION (US) 2004-04-21 EP disclosed
US-6638927-B2 Melanocortin-4 receptor (MC4-R) agonists; treating obesity or diabetes; 4-((N-cyclohexyl-3,5-dimethyl-piperazine-1-carboximidoyl)-amino)-N-(2-(2,4 -dichlorophenyl) -ethyl)-benzamide for example CHIRON CORPORATION 2003-10-28 US disclosed
US-20030199499-A1 Novel guanidinobenzamides CHIRON CORPORATION 2003-10-23 US disclosed
US-20020137939-A1 Melanocortin-4 receptor (MC4-R) agonists; treating obesity or diabetes; 4-((N-cyclohexyl-3,5-dimethyl-piperazine-1-carboximidoyl)-amino)-N-(2-(2,4 -dichlorophenyl)-ethyl)-benzamide for example CHIRON CORPORATION 2002-09-26 US disclosed
WO-2002018327-A2 GUANIDINOBENZAMIDES AS MC4-R AGONISTS CHIRON CORPORATION (US) 2002-03-07 WO disclosed
US-4140717-A Process for halogenating α,α-dialkoxyalkyl ketoximes ALLIED CHEMICAL CORPORATION (US) 1979-02-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060173205-A1 Process for producing w-cyanoaldehyde compound FASN, ALOX5, ALOX15B ALDH1A1 692/4885KDM4E 2068/4885USP2 2036/4885
US-20260001838-A1 NANOMATERIALS SLC10A1, NPC1L1, FABP1 ALDH1A1 619/4885KDM4E 1939/4885USP2 3993/4885
US-20030199499-A1 Novel guanidinobenzamides GUCY1B2, GPR119, GUCY1B1 ALDH1A1 1371/4885KDM4E 686/4885USP2 2774/4885
US-20230331657-A1 NANOMATERIALS COMPRISING ESTER-LINKED ACETALS LIPA, SGMS1, SGMS2 ALDH1A1 331/4885KDM4E 1523/4885USP2 1129/4885
US-12435035-B2 Nanomaterials NPC1, NPC1L1, FABP1 ALDH1A1 984/4885KDM4E 4299/4885USP2 4124/4885
US-20250387509-A1 NANOMATERIALS COMPRISING A BIODEGRADABLE FEATURE LDLR, TGFBR2, MSR1 ALDH1A1 1706/4885KDM4E 627/4885USP2 2604/4885
US-12268753-B2 Nanomaterials comprising a biodegradable feature LIPA, CD63, LIPG ALDH1A1 2294/4885KDM4E 3930/4885USP2 1009/4885
US-20020137939-A1 Melanocortin-4 receptor (MC4-R) agonists; treating obesity or diabetes; 4-((N-cyclohexyl-3,5-dimethyl-piperazine-1-carboximidoyl)-amino)-N-(2-(2,4 -dichlorophenyl)-ethyl)-benzamide for example MC4R, MC5R, MC3R ALDH1A1 2079/4885KDM4E 493/4885USP2 3684/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.