Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 11/20 | 0.32 |
| ▸ | CTSL | P07711 | 11/20 | 0.32 |
| ▸ | CTSS | P25774 | 7/20 | 0.32 |
| ▸ | CTSB | P07858 | 5/20 | 0.32 |
| ▸ | CTSV | O60911 | 2/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | BMP1 | P13497 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049501 | 0.91 | CTSK (0.40) | HPGDTRPM8CTSKCTSLCTSS | |
| SCHEMBL4045921 | 0.91 | HPGD (0.38) | HPGDGAACTSKCTSLCTSS | |
| SCHEMBL4045043 | 0.90 | HPGD (0.38) | HPGDGAACTSKCTSLCTSS | |
| SCHEMBL4048091 | 0.90 | HPGD (0.38) | HPGDGAACTSKCTSLCTSS | |
| SCHEMBL4038978 | 0.90 | USP30 (0.34) | HPGDTRPM8CTSKCTSLCTSS | |
| SCHEMBL4046322 | 0.89 | CHRNB2 (0.38) | HPGDTRPM8CTSKCTSSCTSB | |
| SCHEMBL4043865 | 0.86 | CTSK (0.36) | HPGDTRPM8CTSKCTSLCTSS | |
| SCHEMBL4043432 | 0.86 | KCNQ1 (0.38) | HPGDGAATRPM8USP30KDM4E | |
| SCHEMBL4045350 | 0.85 | CHRNB2 (0.34) | HPGDTRPM8CTSKUSP30ALDH1A1 | |
| SCHEMBL4043593 | 0.84 | USP2 (0.33) | GAATRPM8CTSKUSP30BMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |