Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042383 | 0.93 | CTSK (0.42) | CHRNB2CHRNA7CHRNA4KCNH2CTSK | |
| SCHEMBL4044034 | 0.92 | CHRNB2 (0.41) | CHRNB2CHRNA7CHRNA4ALDH1A1KDM4E | |
| SCHEMBL4046927 | 0.89 | CHRNA7 (0.41) | CHRNB2CHRNA7CHRNA4CTSKALDH1A1 | |
| SCHEMBL4043031 | 0.88 | HTRA1 (0.37) | CHRNA7CTSKPAX8NAMPTHTRA1 | |
| SCHEMBL4046863 | 0.88 | SMYD3 (0.35) | CHRNB2CHRNA7CHRNA4KCNH2CTSK | |
| SCHEMBL4041663 | 0.87 | CTSK (0.35) | CTSKPAX8PREPFAPSMN1; SMN2 | |
| SCHEMBL4043616 | 0.86 | CTSK (0.35) | CTSKALDH1A1PAX8PREPFAP | |
| SCHEMBL4040431 | 0.86 | CHRNB2 (0.37) | CHRNB2CHRNA7CHRNA4CTSKPSMB5 | |
| SCHEMBL4041999 | 0.85 | HSD17B10 (0.36) | CTSKALDH1A1KDM4EPREPFAP | |
| SCHEMBL4041238 | 0.85 | CHRNB2 (0.36) | CHRNB2CHRNA7CHRNA4CTSKPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |