Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 2/20 | 0.32 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049366 | 0.93 | CTSK (0.38) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4047814 | 0.93 | CHRNB2 (0.36) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4043537 | 0.91 | PIK3CG (0.37) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4045350 | 0.90 | CHRNB2 (0.34) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4049417 | 0.89 | CHRNB2 (0.40) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4050896 | 0.89 | HPGD (0.34) | ALDH1A1HPGDCTSVCTSLCTSS | |
| SCHEMBL4048699 | 0.85 | CTSK (0.40) | CTSVCTSLCTSSCTSK | |
| SCHEMBL4045633 | 0.85 | CTSK (0.41) | ALDH1A1MAPTCTSVCTSLCTSS | |
| SCHEMBL4043880 | 0.85 | CHRNB2 (0.41) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4046940 | 0.84 | KDM4E (0.35) | ALDH1A1HPGDMAPTCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |