Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047148 | 0.93 | CHRNB2 (0.39) | PIK3CGKCNQ1CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL4043869 | 0.93 | KCNQ1 (0.37) | PIK3CGKCNQ1CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL4049417 | 0.91 | CHRNB2 (0.40) | PIK3CGCHRNB2CHRNA7CHRNA4KMT2A | |
| SCHEMBL4043842 | 0.91 | CHRNB2 (0.36) | PIK3CGCHRNB2CHRNA7CHRNA4KMT2A | |
| SCHEMBL4049248 | 0.90 | CTSV (0.31) | KCNQ1POLBSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4043432 | 0.90 | KCNQ1 (0.38) | PIK3CGKCNQ1CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL4048699 | 0.88 | CTSK (0.40) | — | |
| SCHEMBL4043880 | 0.86 | CHRNB2 (0.41) | CHRNB2CHRNA7CHRNA4KMT2AALDH1A1 | |
| SCHEMBL4050896 | 0.85 | HPGD (0.34) | SMN1; SMN2ALDH1A1HPGDKDM4ENPSR1 | |
| SCHEMBL4045043 | 0.85 | HPGD (0.38) | POLBALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |