Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | CHUK | O15111 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3981166 | 0.86 | PTGS2 (0.41) | PLATKDM1APTGS1PTGS2FAAH | |
| SCHEMBL3977929 | 0.84 | CYP4F2 (0.41) | RORCPLATKDM1APTGS1PTGS2 | |
| SCHEMBL4053994 | 0.82 | GPR119 (0.42) | RORCATR | |
| SCHEMBL4048443 | 0.79 | RORC (0.47) | RORCPLATKDM1APTGS1PTGS2 | |
| SCHEMBL13690547 | 0.78 | GPR119 (0.57) | — | |
| SCHEMBL4051113 | 0.77 | GPR119 (0.60) | RORC | |
| SCHEMBL4059095 | 0.76 | SMN1; SMN2 (0.45) | RORC | |
| SCHEMBL4050547 | 0.76 | KDM1A (0.49) | KDM1APTGS1PTGS2IKBKBCHUK | |
| SCHEMBL4056907 | 0.74 | TPH1 (0.47) | PLATKDM1APTGS1PTGS2FAAH | |
| SCHEMBL14640643 | 0.72 | GPR119 (0.48) | PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |