Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3983476 | 0.86 | PLAT (0.39) | PLATKDM1APTGS2PTGS1FAAH | |
| SCHEMBL5079994 | 0.84 | RORC (0.41) | RORCPLATFAAHKCNH2GPR119 | |
| SCHEMBL5084438 | 0.83 | PLAT (0.36) | PLATPTGS2PTGS1KCNH2IKBKB | |
| SCHEMBL13690331 | 0.82 | NPC1 (0.41) | ATRNOS3NOS1NOS2 | |
| SCHEMBL4060086 | 0.82 | RORC (0.46) | RORCATRGPR119 | |
| SCHEMBL4053567 | 0.79 | GPR119 (0.47) | RORCGPR119 | |
| SCHEMBL4048433 | 0.79 | RORC (0.41) | RORCPLATKDM1APTGS2PTGS1 | |
| SCHEMBL4387698 | 0.78 | RORC (0.47) | RORCATRGPR119 | |
| SCHEMBL4048482 | 0.78 | GPR119 (0.56) | RORCGPR119 | |
| SCHEMBL4056917 | 0.76 | NPY2R (0.48) | RORCGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |