Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TACR2 | P21452 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050955 | 0.91 | CTSK (0.37) | HPGDFAAHTRPV1 | |
| SCHEMBL4047235 | 0.89 | CTSL (0.36) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL4046100 | 0.88 | KLK7 (0.35) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL4040665 | 0.88 | HPGD (0.38) | HPGDALDH1A1KDM4EHSD17B10FAAH | |
| SCHEMBL4045182 | 0.85 | KCNQ1 (0.37) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL4047338 | 0.83 | TACR2 (0.33) | ALDH1A1KDM4EHSD17B10FAAHTRPV1 | |
| SCHEMBL4044715 | 0.83 | MMP1 (0.34) | ALDH1A1KDM4EHSD17B10FAAHTRPV1 | |
| SCHEMBL4043466 | 0.83 | CHRNB2 (0.40) | HPGDALDH1A1KDM4EKMT2ATACR2 | |
| SCHEMBL4046667 | 0.83 | CTSK (0.37) | HPGD | |
| SCHEMBL4050896 | 0.82 | HPGD (0.34) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |