Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.30 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.30 |
| ▸ | TACR2 | P21452 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 2/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048915 | 0.87 | SMYD3 (0.34) | GPR132 | |
| SCHEMBL4042619 | 0.84 | HPGD (0.33) | SMN1; SMN2 | |
| SCHEMBL4048571 | 0.83 | MEN1 (0.32) | — | |
| SCHEMBL4046730 | 0.82 | CTSL (0.36) | SMN1; SMN2 | |
| SCHEMBL4042884 | 0.81 | CTSK (0.41) | PAX8ALDH1A1 | |
| SCHEMBL4051435 | 0.81 | HTRA1 (0.33) | PAX8GPR132TNKSPARP1PARP2 | |
| SCHEMBL4038641 | 0.81 | CTSK (0.33) | PAX8GPR132ALDH1A1TNKSPARP1 | |
| SCHEMBL4043944 | 0.80 | CTSK (0.33) | PAX8ALDH1A1 | |
| SCHEMBL4041874 | 0.79 | CHRNB2 (0.37) | PAX8SMN1; SMN2NAMPT | |
| SCHEMBL4048563 | 0.78 | HDAC1 (0.40) | GPR132 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |