Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.32 |
| ▸ | CTSV | O60911 | 2/20 | 0.31 |
| ▸ | CTSL | P07711 | 2/20 | 0.31 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.30 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042884 | 0.92 | CTSK (0.41) | PAX8CTSKCTSLCTSS | |
| SCHEMBL4038641 | 0.91 | CTSK (0.33) | PAX8CTSKF2GPR132TNKS | |
| SCHEMBL4043944 | 0.90 | CTSK (0.33) | PAX8CTSKCTSS | |
| SCHEMBL4044323 | 0.87 | SMYD3 (0.33) | F2GPR132 | |
| SCHEMBL4051011 | 0.85 | HCRTR2 (0.34) | CTSVCTSLCTSS | |
| SCHEMBL4044672 | 0.83 | CTSV (0.33) | CTSKCTSVCTSLCTSS | |
| SCHEMBL4044727 | 0.83 | CTSK (0.38) | CTSKCTSVCTSLCTSS | |
| SCHEMBL4050975 | 0.82 | CTSK (0.43) | PAX8CTSKCTSLCTSS | |
| SCHEMBL4043616 | 0.82 | CTSK (0.35) | HTRA1PAX8CTSKGPR132CYP3A4 | |
| SCHEMBL4041667 | 0.82 | HTRA1 (0.38) | HTRA1CTSKGPR132CTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |