Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.36 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28204350 | 0.79 | IDO1 (0.36) | ENPP2ORAI1ORAI2ORAI3MAOB | |
| SCHEMBL29410834 | 0.78 | ENPP2 (0.41) | ENPP2ALDH1A1IDO1LMNAKMT2A | |
| SCHEMBL4288 | 0.78 | ENPP2 (0.41) | ENPP2ALDH1A1IDO1LMNAKMT2A | |
| SCHEMBL28043678 | 0.78 | MEN1 (0.36) | ENPP2MAOBALDH1A1IDO1LMNA | |
| SCHEMBL19088669 | 0.77 | KDM4E (0.40) | ALDH1A1IDO1LMNAKMT2AMEN1 | |
| SCHEMBL29063513 | 0.76 | PPARG (0.39) | ENPP2ORAI1ORAI2ORAI3MAOB | |
| SCHEMBL3826025 | 0.75 | HSD11B1 (0.33) | ENPP2ORAI1ORAI2ORAI3IDO1 | |
| SCHEMBL2408381 | 0.74 | TRPV6 (0.42) | ORAI1ORAI2ORAI3ALDH1A1IDO1 | |
| SCHEMBL28107366 | 0.70 | ENPP2 (0.37) | ENPP2ORAI1ORAI2ORAI3ALDH1A1 | |
| SCHEMBL813858 | 0.69 | ALDH1A1 (0.41) | ALDH1A1IDO1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111501-A1 | DERIVATIVES OF IMIDAZO [4, 5-D] PYRIDAZINE AND THEIR USE AS ANTI-VIRAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |