SCHEMBL4288

SCHEMBL4288

OB(O)c1ccccc1C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 1/20 0.41
LMNA P02545 1/20 0.39
GAA P10253 1/20 0.39
ALDH1A1 P00352 1/20 0.39
POLB P06746 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
HSD11B1 P28845 1/20 0.38
NFKB1 P19838 1/20 0.38
MGLL Q99685 2/20 0.38
TRPV6 Q9H1D0 1/20 0.38
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
CA2 P00918 1/20 0.36
IDO1 P14902 1/20 0.36
NOS3 P29474 1/20 0.36
NOS1 P29475 1/20 0.36
NOS2 P35228 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29410834 1.00 ENPP2 (0.41) ENPP2LMNAGAAALDH1A1POLB
SCHEMBL2408381 0.86 TRPV6 (0.42) LMNAGAAALDH1A1POLBTDP1
SCHEMBL20975383 0.84 ENPP2 (0.40) ENPP2ALDH1A1TDP1MGLLTRPV6
SCHEMBL7394302 0.83 HSD11B1 (0.46) ALDH1A1TDP1HSD11B1
SCHEMBL28702822 0.80 TAS2R14 (0.41) ENPP2ALDH1A1HSD11B1MGLLCA2
SCHEMBL187809 0.80 CA2 (0.41) ENPP2LMNAGAAMGLLCA2
SCHEMBL29525986 0.80 MGLL (0.38) HSD11B1MGLLCA2IDO1
SCHEMBL31156210 0.80 TAS2R14 (0.41) ENPP2ALDH1A1HSD11B1MGLLCA2
SCHEMBL1669643 0.80 HSD11B1 (0.40) ENPP2LMNAGAAHSD11B1MGLL
SCHEMBL29955679 0.80 CA2 (0.41) ENPP2LMNAGAAMGLLCA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2885 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122060240-A Long-acting antistatic PE packaging film material and preparation method thereof 广州星辰包装有限公司 2026-05-19 CN claimed
US-20250194617-A1 Materials and Methods for Extending Shelf-Life of Foods JP LABORATORIES, INC. 2025-06-19 US claimed
US-20250169514-A1 Materials and Methods for Extending Shelf-Life of Foods JP LABORATORIES, INC. 2025-05-29 US claimed
US-12221435-B2 Organic molecules, in particular for use in optoelectronic devices SAMSUNG DISPLAY CO., LTD. (KR) 2025-02-11 US claimed
CN-118878402-A Preparation method of trifluoromethyl ketone compound based on palladium catalysis of C-N bond cleavage 大连理工大学 2024-11-01 CN claimed
CN-118652208-A Preparation method of mineralocorticoid receptor antagonist Ai Shali ketone key intermediate axial chiral pyrrole 大连理工大学 2024-09-17 CN claimed
CN-118344378-A Beta-axis chiral porphyrin compound and preparation method thereof through Suzuki coupling reaction 同济大学 2024-07-16 CN claimed
CN-118307536-A 4, 7-Bis (3, 5-bis (trifluoromethyl) phenyl) -1, 10-phenanthroline framework ligand and synthesis method and application thereof 浙江工业大学 2024-07-09 CN claimed
CN-114456098-B Preparation method of medicine Ai Shali ketone for treating diabetic nephropathy 大连理工大学 2024-06-14 CN claimed
CN-118084682-A Tetraphenylenediamine monomer containing trifluoromethyl and preparation method and application thereof 株洲时代新材料科技股份有限公司 2024-05-28 CN claimed
WO-2012170377-A1 PROCESS FOR PREPARING [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC ACIDS, ESTERS AND AMIDES AKEBIA THERAPEUTICS INC. (US) 2012-12-13 WO claimed
US-20120309977-A1 PROCESS FOR PREPARING [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC ACIDS, ESTERS AND AMIDES AKEBIA THERAPEUTICS INC. (US) 2012-12-06 US claimed
US-20100040538-A1 Polymer Systems for Lung Volume Reduction Therapy CANADIAN IMPERIAL BANK OF COMMERCE (CA) 2010-02-18 US claimed
EP-2059227-A2 POLYMER SYSTEMS FOR LUNG VOLUME REDUCTION THERAPY Aeris Therapeutics, Inc. (US) 2009-05-20 EP claimed
WO-2008039827-A2 POLYMER SYSTEMS FOR LUNG VOLUME REDUCTION THERAPY AERIS THERAPEUTICS, INC. (US) 2008-04-03 WO claimed
EP-1313560-A4 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION UNIV YALE (US) 2005-02-09 EP claimed
EP-1313560-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2003-05-28 EP claimed
WO-2002011883-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2002-02-14 WO claimed
EP-1107982-A1 REVERSIBLE BORONATE COMPLEXES OF 1,2-$i(CIS)-DIOL CYCLIC-PEPTIDES Eli Lilly & Company (US) 2001-06-20 EP claimed
WO-2000012540-A1 REVERSIBLE BORONATE COMPLEXES OF 1,2-CIS-DIOL CYCLIC-PEPTIDES ELI LILLY AND COMPANY (US) 2000-03-09 WO claimed