Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4911102 | 0.86 | MAPT (0.59) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL4921736 | 0.84 | MAPT (0.59) | KMT2AMEN1ALDH1A1GAAMAPT | |
| SCHEMBL9396580 | 0.83 | MEN1 (0.48) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL9398335 | 0.82 | PKM (0.47) | PKMKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL11638233 | 0.80 | PTK2 (0.59) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL15440489 | 0.79 | HPGD (0.53) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL10734797 | 0.78 | MEN1 (0.43) | KMT2AMEN1ALDH1A1HPGDNPSR1 | |
| SCHEMBL4113307 | 0.77 | MAPT (0.77) | KMT2AMEN1ALDH1A1GAAPOLB | |
| SCHEMBL10728971 | 0.76 | MEN1 (0.42) | KMT2AMEN1ALDH1A1HPGDNPSR1 | |
| SCHEMBL31469754 | 0.76 | MEN1 (0.50) | KMT2AMEN1ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697381-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20070149553-A1 | Mitotic kinesin inhibitors | ARRINGTON KENNETH L | 2007-06-28 | — | — | US | disclosed |
| US-20070149553-A1 | Mitotic kinesin inhibitors | ARRINGTON KENNETH L | 2007-06-28 | — | — | US | disclosed |
| US-20070149553-A1 | Mitotic kinesin inhibitors | ARRINGTON KENNETH L | 2007-06-28 | — | — | US | disclosed |
| EP-1697381-A1 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061518-A1 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149553-A1 | Mitotic kinesin inhibitors | KIF5B, KIF2C, KIF18B | TLR2 4878/4885MAPK14 1949/4885RAF1 2005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.