Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CBX7 | O95931 | 4/20 | 0.44 |
| ▸ | CDYL2 | Q8N8U2 | 4/20 | 0.44 |
| ▸ | CDYL | Q9Y232 | 4/20 | 0.44 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246933 | 0.89 | KMO (0.55) | KMOALDH1A1HPGDGAAMAOB | |
| SCHEMBL29999740 | 0.83 | KDM4E (0.47) | KMOALDH1A1HPGDMAOBLMNA | |
| SCHEMBL8296662 | 0.75 | L3MBTL1 (0.60) | KMOALDH1A1HPGDLMNATP53 | |
| SCHEMBL4242148 | 0.73 | KMO (0.61) | KMOLMNATP53CBX7CDYL2 | |
| SCHEMBL8463444 | 0.72 | KDM4E (0.44) | ALDH1A1HPGDLMNATP53KDM4E | |
| SCHEMBL4413088 | 0.72 | HPGD (0.59) | KMOHPGDLMNATP53CBX7 | |
| SCHEMBL13140318 | 0.72 | TP53 (0.58) | KMOALDH1A1HPGDLMNATP53 | |
| SCHEMBL8177728 | 0.71 | KMO (0.55) | KMOALDH1A1HPGDLMNATP53 | |
| SCHEMBL2955732 | 0.70 | KMO (0.51) | KMOALDH1A1HPGDLMNATP53 | |
| SCHEMBL14553919 | 0.70 | OGT (0.60) | KMOALDH1A1LMNACBX7CDYL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049118-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008011551-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-24 | — | — | WO | disclosed |