Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL27456670 | 0.95 | HRH3 (0.42) | SLC18A3MAOAMAOBMAPTL3MBTL1 | |
| SCHEMBL27865561 | 0.83 | ALDH1A1 (0.42) | SLC18A3MAOAMAOBMAPTL3MBTL1 | |
| SCHEMBL27700616 | 0.82 | MBTD1 (0.40) | SLC18A3MAOAMAOBMAPTL3MBTL1 | |
| SCHEMBL11030898 | 0.81 | FFAR1 (0.38) | SLC18A3MAOAMAOBL3MBTL1MBTD1 | |
| SCHEMBL27848433 | 0.81 | OPRM1 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL30241932 | 0.81 | CHRNB2 (0.48) | MAPTALDH1A1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL11498525 | 0.81 | FFAR1 (0.40) | SLC18A3MAOAMAOBL3MBTL1MBTD1 | |
| SCHEMBL27972498 | 0.79 | SLC18A3 (0.46) | SLC18A3ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL10731523 | 0.79 | FFAR1 (0.34) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL27630324 | 0.79 | FFAR1 (0.46) | MAPTL3MBTL1KDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104470924-B | Imidazopyrazines derivant as TNF active regulator | UCB生物制药私人有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-105492460-A | Stabilized polypeptide insulin receptor modulators | HARVARD COLLEGE | 2016-04-13 | — | — | CN | disclosed |
| CN-105492428-A | Methods and compositions for treating beta-thalassemia and sickle cell disease | ACADEMIA SINICA | 2016-04-13 | — | — | CN | disclosed |
| CN-105164161-A | Neuroactive steroids, compositions, and uses thereof | SAGE THERAPEUTICS INC | 2015-12-16 | — | — | CN | disclosed |
| CN-104936595-A | Methods and compositions for locally increasing body fat | TOPOKINE THERAPEUTICS INC | 2015-09-23 | — | — | CN | disclosed |
| CN-104136452-A | 3, 3-disubstituted 19-norpregnane compounds, compositions, and uses thereof | SAGE THERAPEUTICS INC | 2014-11-05 | — | — | CN | disclosed |
| CN-103958540-A | Neuroactive steroids, compositions, and uses thereof | SAGE THERAPEUTICS INC | 2014-07-30 | — | — | CN | disclosed |
| US-8754107-B2 | Aminopyrrolidines as chemokine receptor antagonists | ABBVIE INC. (US) | 2014-06-17 | — | — | US | disclosed |
| EP-2099454-A2 | AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS | Abbott Laboratories (US) | 2009-09-16 | — | — | EP | disclosed |
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | ABBVIE INC. | 2008-07-24 | — | — | US | disclosed |
| WO-2008060621-A2 | AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2008-05-22 | — | — | WO | disclosed |
| US-5773437-A | UROGENITAL DISORDERS SUCH AS DYSURIA | NIPPON CHEMIPHAR CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | MIF, CCL5, CCR2 | SLC18A3 4789/4885MAOA 3462/4885MAOB 3552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.