Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 13/20 | 0.59 |
| ▸ | MMP2 | P08253 | 3/20 | 0.56 |
| ▸ | MMP9 | P14780 | 3/20 | 0.56 |
| ▸ | MMP8 | P22894 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | FCER2 | P06734 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063159 | 0.83 | CCR1 (0.56) | CCR1 | |
| SCHEMBL4064106 | 0.83 | CCR1 (0.56) | CCR1 | |
| SCHEMBL4058892 | 0.82 | CCR1 (0.53) | CCR1 | |
| SCHEMBL7591101 | 0.82 | CCR1 (0.53) | CCR1 | |
| SCHEMBL4069710 | 0.81 | MMP1 (0.56) | CCR1MMP2MMP9MMP8 | |
| SCHEMBL4065207 | 0.81 | CCR1 (0.45) | CCR1 | |
| SCHEMBL4063348 | 0.81 | CCR1 (0.54) | CCR1MMP2MMP9MMP8 | |
| SCHEMBL4068036 | 0.81 | REN (0.62) | CCR1MMP9MMP8 | |
| SCHEMBL4066989 | 0.81 | REN (0.62) | CCR1MMP9MMP8 | |
| Hydrochloric Acid SCHEMBL9876361 | 0.77 | METAP2 (0.59) | CCR1MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |
| EP-1051405-B1 | NOVEL DIHYDROXYHEXANOIC ACID DERIVATIVES | PFIZER PROD INC (US) | 2006-08-23 | — | — | EP | disclosed |
| US-6673801-B1 | TREATING MULTIPLE SCLEROSIS OR RHEUMATOID ARTHRITIS | PFIZER INC. | 2004-01-06 | — | — | US | disclosed |
| US-20030018033-A1 | Novel dihydroxyhexanoic acid derivatives | KATH JOHN CHARLES (US) | 2003-01-23 | — | — | US | disclosed |
| US-20020198207-A1 | Novel Hexanoic acid derivatives | KATH JOHN CHARLES (US) | 2002-12-26 | — | — | US | disclosed |
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |
| EP-1051405-A2 | NOVEL DIHYDROXYHEXANOIC ACID DERIVATIVES | Pfizer Products Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| EP-0966443-A1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER INC. (US) | 1999-12-29 | — | — | EP | disclosed |
| WO-1999040061-A2 | NOVEL DIHYDROXYHEXANOIC ACID DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1999-08-12 | — | — | WO | disclosed |
| WO-1998038167-A1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER INC. (US) | 1998-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018033-A1 | Novel dihydroxyhexanoic acid derivatives | HCAR1, HCAR2, SLC27A1 | CCR1 180/4885MMP2 3347/4885MMP9 3862/4885 |
| US-20020198207-A1 | Novel Hexanoic acid derivatives | HCAR3, HCAR1, FFAR1 | CCR1 21/4885MMP2 4427/4885MMP9 4307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.